joint effects of obesity and vitamin d insufficiency on insulin resistance

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1、Epidemiology/HealthServicesResearchORIGINALARTICLEJointEffectsofObesityandVitaminDInsufficiencyonInsulinResistanceandType2DiabetesResultsfromtheNHANES2001–2006SHAUMM.KABADI,MPHwithadultsthathadalowBMIafterfullBRIANK.LEE,PHDcovariateadjustment(15).LONGJIANLIU,

2、MD,PHD,MSCBecauseofdecreasedbioavailabilityofvitaminDduetoexcessstorageinbodyfatcompartments,obesitymayinteractwithOBJECTIVEdThepossibleinteractionofserum25-hydroxyvitaminD[25(OH)D]andobe-vitaminDtosynergisticallyinfluenceriskofsityinregardtotype2diabetesandi

3、nsulinresistancehasnotbeenwellstudied.Toexploretheinsulinresistanceandtype2diabetes(18).effectmodificationofobesityontheassociationbetween25(OH)Dandinsulinresistance/type2However,thepossibleinteractionofvitamindiabetes,datawereexaminedfromanationallyrepresent

4、ativesample.Dandobesitywithregardtotype2diabetesRESEARCHDESIGNANDMETHODSdTheanalyticsampleforthetype2diabetesandinsulinresistancehasnotbeenwellanalysis(n=12,900)waslimitedtoparticipantsfromtheNationalHealthandNutritionExam-studied.Inarecentlypublishedstudy,t

5、heinationSurvey(NHANES)2001–2006over20yearsofage.Participants.20yearsofageassociationofserum25(OH)Dconcentra-assignedtothemorningsessionandfreeofdiabeteswerelimitedtotheinsulinresistanceanalysistionwithinsulinsensitivitywasfoundtobe(n=5,806).Multiplicativein

6、teractionwasassessedthroughacross-productinteractionterminastrongerinoverweightindividualsthaninmultiplelogisticregressionmodel.Thepresenceofadditiveinteractionbetweeninsufficientnormal-weightindividuals(19).Although25(OH)Dandobesity(indicatedbyBMIorwaistcirc

7、umference)wasevaluatedbycalculationofsuggestive,thisstudywaslimitedinthatittherelativeexcessriskduetointeraction(RERI)andattributableproportionduetointeraction(AP).featuredasmallsampleofyoungeradultsRESULTSdTherewasnomultiplicativeinteractionofinsufficient25(

8、OH)Dandobesityontype2fromauniversitycampuswithlimiteddiabetesorinsulinresistance.Furthermore,noneoftheRERIorAPvalueswerestatisticallyracial/ethnicgroups.Tofurtherexploresignificantinthediabetesan