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1、ThenewenglandjournalofmedicineoriginalarticleAPooledAnalysisofVitaminDDoseRequirementsforFracturePreventionHeikeA.Bischoff-Ferrari,M.D.,Dr.P.H.,WalterC.Willett,M.D.,Dr.P.H.,EndelJ.Orav,Ph.D.,PaulLips,M.D.,PierreJ.Meunier,M.D.,RonanA.Lyons,M.D.,M.P.H.,LeonFlicker,M.D.,JohnWark,M.D.,Ph.D.,R
2、ebeccaD.Jackson,M.D.,JaneA.Cauley,Dr.P.H.,HaakonE.Meyer,M.D.,Ph.D.,MichaelPfeifer,M.D.,KerrieM.Sanders,Ph.D.,HannesB.Stähelin,M.D.,RobertTheiler,M.D.,andBessDawson-Hughes,M.D.FromtheCenteronAgingandMobility,UniversityofZurichandWaidCityHospi-tal,Zurich,andtheDepartmentofRheu-ABSTRACTmatol
3、ogy,UniversityHospitalZurich,Zurich(H.A.B.-F.),theDepartmentofRheumatology,CityHospitalTriemli,Zu-rich(R.T.),andtheDepartmentofGeriat-BACKGROUNDrics,UniversityHospitalBasel,BaselTheresultsofmeta-analysesexaminingtherelationshipbetweenvitaminDsupple-(H.B.S.)—allinSwitzerland;theDepart-ment
4、ationandfracturereductionhavebeeninconsistent.mentsofNutrition(W.C.W.)andBiosta-tistics(E.J.O.),HarvardSchoolofPublicHealth,andtheBoneMetabolismLabo-METHODSratory,JeanMayerUSDAHumanNutritionWepooledparticipant-leveldatafrom11double-blind,randomized,controlledtrialsResearchCenteronAgingatT
5、uftsUni-versity(B.D.-H.)—bothinBoston;theoforalvitaminDsupplementation(daily,weekly,orevery4months),withorwithoutDepartmentofInternalMedicineandEn-calcium,ascomparedwithplaceboorcalciumaloneinpersons65yearsofageordocrinologyandtheEMGOInstituteforolder.Primaryendpointsweretheincidenceofhip
6、andanynonvertebralfracturesHealthandCareResearch,VUUniversityMedicalCenter,Amsterdam(P.L.);ClaudeaccordingtoCoxregressionanalyses,withadjustmentforagegroup,sex,typeofBernardUniversityofLyon,Lyon,Francedwelling,andstudy.Ourprimaryaimwastocomparedatafromquartilesofac-(P.J.M.);theDepartmento
7、fPublicHealth,SwanseaUniversity,Swansea,UnitedKing-tualintakeofvitaminD(includingeachindividualparticipant’sadherencetothedom(R.A.L.);theWesternAustraliantreatmentandsupplementuseoutsidethestudyprotocol)inthetreatmentgroupsCentreforHealthandAgeing,Universityofalltri
