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1、ROXISARA AMComposition:EachtabletofRoxisaraAMcontainsroxithromycin150mgandambroxolhydrochloride30mg.Description:Roxithromycinisasemisynthetic,long-acting,acid-stablemacrolideantibiotic.Ascomparedtoerythromycin,ithasaverysimilarantibacterialspectrumofaction,betterbioavailabilitybytheoralroute
2、,bettertissuepenetration,andmuchlongerdurationofaction.ChemicallyitisdesignatedasErythromycin9-{0-[(2-methoxyethoxyl)methyl]oxime}(C41H76N2O15=837.0).Ambroxolisanactivemetaboliteofbromhexineandhassimilarbutsomewhatlonger-lastingmucolyticaction.Chemicallyambroxol(ashydrochloridesalt)isdesigna
3、tedastrans-4-(2-Amino-3,5dibromobenzylamino)cyclohexanolhydrochloride(C13H18Br2N2O1HCl=414.6).IthasbeenincorporatedintabletRoxisaraAMtofacilitatebetterpenetrationofroxithromycinintorespiratorytractfluidsforsuperiorantibacterialaction.PharmacologicalActionsandTheirMechanisms:Roxithromycinishi
4、ghlyactiveagainstStreptococcuspyogenesandS.pneumoniae,Staphylococcusaureus(methicillin-sensitive)*,Clostridia,Corynebacteriumdiphtheriae,Bacillusanthracis,Erysipelothrixrhusiopathy,Listeriamonocytogenes,Propionibacteriumacnes,andalsoagainstNeisseriagonorrhoeae,Moraxellacatarrhalis,Campylobac
5、ter,Gardnerellavaginalis,Legionellapneumophilia,andMycoplasmapneumoniae.OrganismsmoderatelysensitivetothedrugincludeS.viridans,N.meningitides,Haemophilusducrei,H.Influenzae,Helicobacterpylori,Bordetellapertussis,Campylobacterjejuni,Actinomyces,Chlamydiatrachomatis,Rickettsias,Treponemapallid
6、um,Borreliaburgdorferi,andmycobacteriumscrofulaceumandM.kansasi.(*Somestrainsmaydevelopresistanceduringthecourseoftherapywith5roxithromycin).Roxithromycinbindstothe50Sribosomalsubunitofsusceptiblebacteriaandinhibitstheirgrowthandmultiplicationbydisruptingbacterialproteinsynthesis.Ambroxolliq
7、uefiestenaciousrespiratorytractsecretionsbydepolymerisingmucopolysaccharidefibresdirectlyaswellasbyliberatinglysosomalenzymes.Italsoincreasesthesecretionofthinbronchialfluids.Suchmucolyticandmucokineticactionsfacilitatepenetrationofantimicrobialage
