资源描述：
《01罗红霉素盐酸氨溴索片英文说明书》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。
1、ROXISARA AMComposition:EachtabletofRoxisaraAMcontainsroxithromycin150mgandambroxolhydrochloride30mg.Description:Roxithromycinisasemisynthetic,long-acting,acid-stablemacrolideantibiotic.Ascomparedtoerythromycin,ithasaverysimilarantibacterialspectrumofaction,betterbioavailabi
2、litybytheoralroute,bettertissuepenetration,andmuchlongerdurationofaction.ChemicallyitisdesignatedasErythromycin9-{0-[(2-methoxyethoxyl)methyl]oxime}(C41H76N2O15=837.0).Ambroxolisanactivemetaboliteofbromhexineandhassimilarbutsomewhatlonger-lastingmucolyticaction.Chemicallyam
3、broxol(ashydrochloridesalt)isdesignatedastrans-4-(2-Amino-3,5dibromobenzylamino)cyclohexanolhydrochloride(C13H18Br2N2O1HCl=414.6).IthasbeenincorporatedintabletRoxisaraAMtofacilitatebetterpenetrationofroxithromycinintorespiratorytractfluidsforsuperiorantibacterialaction.Phar
4、macologicalActionsandTheirMechanisms:RoxithromycinishighlyactiveagainstStreptococcuspyogenesandS.pneumoniae,Staphylococcusaureus(methicillin-sensitive)*,Clostridia,Corynebacteriumdiphtheriae,Bacillusanthracis,Erysipelothrixrhusiopathy,Listeriamonocytogenes,Propionibacterium
5、acnes,andalsoagainstNeisseriagonorrhoeae,Moraxellacatarrhalis,Campylobacter,Gardnerellavaginalis,Legionellapneumophilia,andMycoplasmapneumoniae.OrganismsmoderatelysensitivetothedrugincludeS.viridans,N.meningitides,Haemophilusducrei,H.Influenzae,Helicobacterpylori,Bordetella
6、pertussis,Campylobacterjejuni,Actinomyces,Chlamydiatrachomatis,Rickettsias,Treponemapallidum,Borreliaburgdorferi,andmycobacteriumscrofulaceumandM.kansasi.(*Somestrainsmaydevelopresistanceduringthecourseoftherapywith5roxithromycin).Roxithromycinbindstothe50Sribosomalsubunito
7、fsusceptiblebacteriaandinhibitstheirgrowthandmultiplicationbydisruptingbacterialproteinsynthesis.Ambroxolliquefiestenaciousrespiratorytractsecretionsbydepolymerisingmucopolysaccharidefibresdirectlyaswellasbyliberatinglysosomalenzymes.Italsoincreasesthesecretionofthinbronchi
8、alfluids.Suchmucolyticandmucokineticactionsfacilitatepenetrationofantimicrobialage
