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1、【摘要】目的观察妇科止血消痛颗粒对药物流产后大鼠血清雌激素、孕激素含量及子宫组织中雌激素受体(ER)、孕激素受体(PR)表达的影响,探讨其治疗药物流产后子宫复旧不全的机制。方法选用SD雌性大鼠72只,随机分为空白组、模型组、产妇康组及妇科止血消痛颗粒高、中、低剂量组。建立大鼠药物流产后子宫复旧不全病理模型。采用放射免疫法检测大鼠血清中雌二醇(E2)、孕酮(P)含量,免疫组化法检测各组大鼠子宫组织中ER、PR的表达水平。结果模型组大鼠血清中E2、P含量及子宫组织中ER、PR表达均低于空白组。妇科止血消痛颗粒高、中、低剂量组用药后,血清中E2
2、含量升高,P含量降低,差异有统计学意义(P<0.05,P<0.01),与产妇康组比较,差异无统计学意义(P>0.05)。妇科止血消痛颗粒中、低剂量组可升高ER的表达,妇科止血消痛中剂量组可升高PR的表达(P<0.05,P<0.01)。结论大鼠药物流产后子宫复旧不全模型E2、P、ER、PR均降低,可能影响了产后子宫内膜的修复,妇科止血消痛颗粒通过升高E2、ER、PR水平,降低P水平,发挥治疗药物流产后子宫复旧不全的作用。【关键词】药物流产;子宫复旧不全;妇科止血消痛颗粒;雌二醇;孕酮;雌激素受体;孕激素受体;大鼠 EffectofFuke
3、ZhixuexiaotongKeliontheExpressionofEstrogen-progestinandItsReceptorinRatsModelofMedicalAbortionYOUZhao-ling,ZENGJing,YOUhui,etal(HunanUniversityofTCM,Changsha410208,China) Abstract：ObjectiveToexplorethemechanismofFukeZhixuexiaotongKeliinratsmodelofmedicalabortion,byobser
4、vingthecontentofE2,PinserumandtheexpressionofER,PRinuterinetissues.MethodsSeventy-twoSDfemaleratswererandomlydividedinto6groups：blankgroup,modelgroup,Chanfukanggroup,FukeZhixuexiaotongKelihigh-,middle-andlow-dosegroup.Themodelofmedicalabortionwasestablished.ThecontentofE2
5、,Pinserumweredetectedbythemethodofimmunoradiometricassay(IRMA)andtheexpressionofER,PRinuterinetissuesbythemothodofimmunohistochemicalstaining(IHC).ResultsBoththecontentofE2,PinserumandtheexpressionofER,PRinuterinetissuesofthemodelgroupwerelowerthantheblankgroup.Thecontent
6、ofE2raisedandPreducedinFukeZhixuexiaotongKelihigh-,middle-,low-dosegroupwithsignificantdifference(P<0.05,P<0.01),andnostatisticalmeaningwithChanfukanggroup(P>0.05).TheexpressionofERwasraisedinFukeZhixuexiaotongKelimiddle-andlow-dosegroup,andtheexpressionofPRwasraisedinFuk
7、eZhixuexiaotongKelimiddle-dosegroup(P<0.05,P<0.01).ConclusionThecontentofE2,P,ERandPRwasreducedinratsmedicalabortionandpostpartumuterineredintegrationincompletemodel,thatmayaffecttherepairofpostpartumuterineendometrial.FukeZhixuexiaotongKeliplayedaroleincuringuterineredin
8、tegrationincompletecausedbymedicalabortion,byraisingthecontentofE2,ERandPR,andreducingthecontent
