最新药剂学专论结课作业概要1ppt课件.ppt

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1、药剂学专论结课作业概要1Catalogue1Abstract2543IntroductionMaterialsandmethodsResultsDiscussion1.AbstractTRAILanddoxorubicincombinationenhancesanti-glioblastomaeffectbasedonpassivetumortargetingofliposomesTRAILGBMGBMGBMGBMGBMGBMGBMGBMGBMTRAILDeadDeadDeadTRAILTRAILTRAIL

2、TRAILTRAILTRAILTRAIL:Tumornecrosisfactor-relatedapoptosis-inducingligand.TRAILanddoxorubicincombinationenhancesanti-glioblastomaeffectbasedonpassivetumortargetingofliposomes2.IntroductionBraintumor43%21%16%11%9%GBMMeningiomaPituitarytumorNeurofibromaOthers

3、Theclassificationandproportionofbraintumor43%2.1TheoutlineofbraintumorTRAILanddoxorubicincombinationenhancesanti-glioblastomaeffectbasedonpassivetumortargetingofliposomes2.Introduction2.2TheoutlineofTRAIL2.2.1ThemolecularmechanismsofTRAILCaspase3,6,7Cellme

4、mbraneTRAIL-DR4/DR5DISCMitochordriaDDFADDDEDProcaspase-8cFLIPActiveCaspase-8TypeⅠTypeⅡBidBax/BakBcl-2/Bcl-xL/Mcl-1CytcApaf-1dATPProcaspace-9Caspase-9SmaccIAPCellmembraneDISCApoptosisTRAIL-DR4/DR5郦萍,吴雪昌.肿瘤细胞抗TRAIL凋亡诱导的分子机制[J].细胞生物学杂志,2006,02:153-1592.2Theout

5、lineofTRAIL2.2.1ThemolecularmechanismsofTRAIL2.2.2TherestrictionofTRAIL'sapoptoticeffectsSomeofGBMcelllinessuchasU87MGandU178MGarerelativelyresistanttotheapoptoticeffectsofTRAIL2.2.3ThestrategytorestoretheTRAIL-inducedapoptoticpotencyTRAIL-basedcombinationc

6、hemotherapeuticregimensarebeingstudied.Doxorubicin(DOX),cansensitizebreastandprostatecancercellstoTRAIL-inducedapoptosisinvivo.TheevaluationoftherapeuticefficiencyofcombinedDOX/TRAILonGBMxenograftsseemsnecessaryandfeasible.2.IntroductionTRAILanddoxorubicinc

7、ombinationenhancesanti-glioblastomaeffectbasedonpassivetumortargetingofliposomesTRAILanddoxorubicincombinationenhancesanti-glioblastomaeffectbasedonpassivetumortargetingofliposomes2.IntroductionThetherapeuticusefulnessofDOXandTRAILcombinationtreatmentisli

8、mitedbythefollowingfactors:ThewideexpressionofTRAILreceptorsonsomaticcellsandshortserumhalflifeofTRAILTherapeuticpotentialofDOXhasbeenlimitedbyitschroniccardiactoxicityTheparticularfeatureofthebrainend