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1、Reproducibilityofcornealtopographicdataderivedfromanterior角膜地形数据来自前的重现性Purpose:ToevaluatethereproducibilityofcornealcurvaturemeasurementsentirelyderivedfromOCTscandata,andtocomparethemtomeasurementsobtainedbymeansofaconventionalPlacidodisctopographer.Methods:101KER
2、ATOCONUSPATIENTSand40NORMALSUBJECTSwereexaminedintheirrighteyewithtwoinstruments:aspectraldomainOCT,dedicatedtoanteriorsegmentexamination(CasiaSS-1000,TomeyCo.,Japan)aconventionalPlacido-disctopographer(KeratronScout,Optikon,Italy)Examinationswerecarriedoutinthesam
3、esessiontwicewitheachdevice,inordertoassessreproducibility.StatisticalanalysiswasperformedwiththeSPSS18.0software.Results:validityofOCTkeratometryPathologiceyesNormaleyesICC=0.985ICC=0.959ACBDA,C:scatterplotsoftheaveragecornealcurvaturevaluesobtainedbyCasiaAS-OCT(x
4、-axis)andKeratrontopographer(y-axis).B,D:Bland-AltmanplotsofCasia-Keratroncomparison,representingthedifferencesofcorrespondingmeasurements(y-axis)inrelationtotheirmeans(x-axis).CornealcurvatureisexpressedinDioptries.Curvaturemeasurementsobtainedwiththetwoinstrument
5、sshowedexcellentagreementbothinthenormalandinthepatientsgroup,withIntra-ClassCorrelationCoefficients(ICC)of0.959and0.985,respectively.Results:reproducibilityInthenormalgroupreproducibility(ICC)ofcurvaturemeasurementswas0.988fortheOCTand0.976fortheconventionaltopogr
6、apher,whileinthepatientsgroupICCforOCTandtopographerwas0.997and0.989,respectively.Scatterplotsoftest(x-axis)vs.re-test(y-axis)averagecornealcurvaturevaluesareshownbelow.CASIAAS-OCTKERATRONTOPOGRAPHERPathologiceyesNormaleyesICC=0,997ICC=0,989ICC=0,988ICC=0,976Furthe
7、ranalysisofreproducibilitywithBland-AltmanplotsrevealedahighervariabilitywiththeconventionaltopographerascomparedtotheOCTinthepatientsgroup(p<0.01),butnotinthenormalgroup(p=0.085).ICCandCoefficientofRepeatability(CR)arereportedinthefiguresbelow.[CR=1,96xSDofthediff
8、erencesbetweenrepeatedmeasures].Results:reproducibilityCASIAAS-OCTKERATRONTOPOGRAPHERNormaleyesICC=0,997ICC=0,989ICC=0,988ICC=0,976Pathologiceyes
