脑影像智能分析与脑疾病早期诊断ppt课件.pptx

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1、脑影像智能分析与脑疾病早期诊断张道强南京航空航天大学BrainProjects美国“脑活动图谱”计划欧盟“人类脑计划”中国脑计划BrainImaging(Neuroimaging)NeuroimagingincludestheuseofvarioustechniquestoeitherdirectlyorindirectlyimagethestructureorfunctionofthebrainTwobroadcategoriesStructuralneuroimagingdealswiththestructureof

2、thebrainFunctionalneuroimagingisusedtoindirectlymeasurebrainfunctionsNeuroimaging-basedClassification(S.Lemm,etal.,Neuroimage,2011)Example:BrainDecoding(NatureFeatureNews,2013)(T.Mitchelletal.,Science,2008)RecoveryMoviesOutlineSummary123BackgroundsonAlzheimer’sDi

3、seaseBrain-imagingbasedAnalysisBrain-networkbasedAnalysis4HistoryofADADwasfirstdescribedbyGermanpsychiatristandneuropathologistAloisAlzheimerin1906andwasnamedafterhimThe51y.o.woman(AugusteDeter)caredbyDr.Alzheimeruntilherdeathin1906.Hedidanautopsy,examinedherbrai

4、n&describedthetypicalabnormalitiesofwhatwouldbecalledlaterAlzheimer’sDiseaseWhatIsAD?ItisthemostcommonformofdementiaThereisnocureforthedisease,whichworsensasitprogresses,andeventuallyleadstodeathMostoften,ADisdiagnosedinpeopleover65yearsofageIn2006,therewere26.6m

5、illionsufferersworldwide,anditispredictedtoaffect1in85peoplegloballyby2050不同年代我国痴呆和AD患者的人数【Lancet.2013】“三高”：患病率高、致残率高、负担重“三低”：就诊率低、诊断率低、治疗率低目前我国AD的患病率【Alzheimer's&Dementia.2013】我国AD现状:CelebritieswithADNormalvs.ADBrainInthenormalbrainthereisalotofhealthybraintissu

6、einthelanguagearea.IntheADaffectedbrainthereislittleinthatareaTherearemanydifferencesbetweenthetwobrainsincludingthememory,sulcus,gyrus,ventricle,andlanguageareas.IntheADbrain,theseareeithershrunkenorstretchedouttounhealthymeasuresNormalvs.ADBrainFormsabnormalclu

7、mpscalledamyloidplaquesandtangledbundlesoffiberscalledneurofibrillarytanglesinthebrainAD自画像1967（早年）1996（患病第2年）1997（患病第3年）199819992000Normalordiseased?(S.Crutch,etal.,LancetNeurology,2012)Normalordiseased?(S.Crutch,etal.,LancetNeurology,2012)ADProgressionADatrophy

8、progresses▫StartsinthemedialtemporalandlimbicareasHippocampusandentorhinalcortex▫Subsequentlyspreadingtoparietalassociationareas▫Finallytofrontalandprimarycor