比较应用氯氨酮和对乙酰氨基酚来防止接受腹式全子宫切除术的患者中瑞芬太尼所引起的痛觉过敏

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1、IntJMedSci. 2012; 9(5):327–333.Publishedonline2012June20. doi:  10.7150/ijms.4222PMCID: PMC3384914AComparisonofKetamineandParacetamolforPreventingRemifentanilInducedHyperalgesiainPatientsUndergoingTotalAbdominalHysterectomyNaimeYalcin,1 SemaTuncerUzun,2 RuhiyeReisli,2 HaleBorazan,2, and Se

2、refOtelcioglu2Authorinformation ► Articlenotes ► CopyrightandLicenseinformation ►Goto:ABSTRACTBackground:Theaimofthisprospective,randomized,placebo-controlledstudywastocomparetheeffectsofketamineandparacetamolonpreventingremifentanilinducedhyperalgesia.Methods: Ninetypatientsundergoingtota

3、labdominalhysterectomywererandomlyassignedtooneofthreegroupstoreceive(I)eithersalineinfusion;(II)0.5mg/kgketamineivbolusor(III)1000mgivparacetamolinfusionbeforeinductionofanesthesia.Untiltheskinclosure,anesthesiawasmaintainedwith0.4µg/kg/minremifentanilinfusioninallgroups,additionallyGroup

4、IIreceived5µg/kg/minketamineinfusion.Pressurepainthresholdsweremeasuredthedaybeforesurgeryduringthepreoperativevisitforbaselinemeasurementsandrepeatedpostoperativelyat24and48hours(hrs).Pressurepainthresholdswereestablishedbydigitalalgometeronthreedifferentperi-incisionalregionsforcalculati

5、ngmeanpressurepainthresholdvalues.Thevisualanaloguescale(VAS),sedationscores,totalmorphineconsumptionandsideeffectswereassessedpostoperatively.Results: Demographiccharacteristics,durationofsurgeryandanesthesiaweresimilarinthethreegroups.Painthresholdsattheincisionregionweresignificantlylow

6、erat24and48hrspostoperativelyinGroupIthantheotherGroups(p<0.05).InGroupІ,painthresholdswerelowercomparedwithpreoperativebaselinevalues.ThresholdsinGroupІІandGroupІІІwerehighercomparedwithpreoperativebaselinevalues(p<0.05)TheVASscoresatallevaluationtimesweresignificantlyhigherinGroupІwhenco

7、mparedtoGroupІІandat2,4,6,12hrswerehigherinGroupIthanGroupІІІ(p<0.05).ThemorphineconsumptionwashigherinGroupІІІat24and48hrspostoperatively(p<0.05).Conclusion: Itwasshownthatketamineandparacetamolwerebotheffectiveinpreventingremifentanilinducedhyperalgesia.Keyw