遗传学试题资料：complex disorders.doc

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1、1.Whenisthefemalegenitalductdevelopmentcompleted?(14.0分)A.At7weeksB.At9-10weeksofgestationC.At10-11weeksofgestationD.At18-20weeksofgestationE.Between8and20weeksofgestation2. Tosaythattwoallelesareinlinkagedisequilibriumimpliesthat: (12.0分)A. Theallelesaresoclosethatrecombi

2、nationneveroccursbetweenthem.B. Theallelesfunctiontogetherinthesamepathway.C. Oneallelearosefromtheotherbymutation.D. Thetwoallelesaretogetherinthesamehaplotypemoreoftenthatpredictedbychance.3. AssociationStudies: (12.0分)A. Cangivefalsepositiveresultsduetopopulationstratif

3、icationB. Includethetransmissiondisequilibriumtest(TDT)C. PositiveassociationstudiesshouldbereplicatedD. AreusedtomapgenesinmultifactorialdisordersE. Requirecloselymatchedcontrolandpatientgroups4. Linkageanalysisismoredifficultinmultifactorialconditionsthaninsingle-genedis

4、ordersbecause: (12.0分)A. Variantsinmorethan1genearelikelytocontributetothedisorderB. Thenumberofaffectedpersonswithininafamilyislikelytobefewerthanforasingle-genedisorderC. ThemodeofinheritanceisusuallyuncertainD.  Somemultifactorialdisordersarelikelytohavemorethan1etiolog

5、yE. ManymultifactorialconditionshavealateageofonsetF. Allofabove.5. Amultifactorialtraitoccursmoreofteninfemalesthanmales.Acouplehaveanaffectedson.Whichofthefollowingistrueregardingtheirriskofrecurrence? (12.0分)A. Recurrenceishigherthaniftheyhadanaffecteddaughter,andismost

6、likelyforafuturedaughter.B. Recurrenceishigherthaniftheyhadanaffecteddaughter,andismostlikelyforafutureson.C. Recurrenceishigherthaniftheyhadanaffecteddaughter,andismostlikelyforafuturedaughter.D. Recurrenceislowerthaniftheyhadanaffecteddaughter,andismostlikelyforafutureda

7、ughter.6. Whichofthefollowingstatementsis incorrect regardingtherecurrenceriskofmultifactorialinheriteddisorders. (12.0分)A. TheriskgetshigherwhenthedegreeofrelationshipincreasesB. TheriskgetshigherwhenthenumberofpatientsinthefamilyincreaseC. Theriskfortheirchildrengetshigh

8、erwhenthepatientsareseriouslyaffectedD. Theriskgetshigherwhenoneorbothparentsareaffected.