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1、Primaryafferentneuronsofthegut（消化道初级感觉神经元）Function:Monitoringandcontrolofthedigestivesystem,including:GeneratingappropriatereflexresponsetothegutlumencontentsParticipatesinreflexesbetweenorgansConveysignalsfromdigestiveorganstotheCNS–TriggerreflexCo-o
2、rdinationwithotherbodysystemRelatetosensationincludingdiscomfort,nausea,painandsatiety1intrinsicandextrinsic内源性和外源性Primaryafferentneurons：Extrinsicprimaryafferentneurons,including:Vagalprimaryafferentneuronhavecellbodiesin(nodoseandjugular)ganglia神经节S
3、pinalprimaryafferentneuronhavecellbodiesindorsalrootgangliaIntestinofugalneuron肠离心神经元Partsoftheafferentlimbsofentero-entericreflexpathwaysHavecellbodiesinENS2Intrinsicprimaryafferentneurons,IPANs,withinENSMyenteric肌间IPANs:respondtoDistortionoftheirpro
4、cessesintheexternalmusclelayerschangesinluminalchemistry,viaprocessesinthemucosa,submucosal粘膜下IPANsdetect:MechanicaldistortionofthemucosaLuminalchemistry.LM,longitudinalmuscle;CM,circularmuscle;MP,myentericplexus;SM,submucosa;Muc,mucosa.Nerveendingsin
5、themucosacanbeactivatedbyhormonesreleasedfromentero-endocrinecells(arrows).3IIntrinsicPrimaryAfferentNeuronsandNerveCircuitswithintheIntestineReference:FurnessJB,JonesC.,NurgaliK.,ClercN.Intrinsicprimaryneuronsandnervecircuitswithintheintestine.Progre
6、ssinNeurobiology2004,72:143-1644TypesofneuronsthatformentericnervecircuitsAccordingtothefunctions,keytransmittersprojectionstotargets5LM:longitudinalmuscle;MP:myentericplexus;CM:circularmuscle;SM:submucosalplexus;Muc:mucosa.MyentericNeuronsAscendingin
7、terneurons(5%)Myentericintrinsicprimaryafferentneurons(26%)Intestinofugalneurons(<1%)Excitatorylongitudinalmusclemotorneurons(25%)Inhibitorylongitudinalmusclemotorneurons(2%)Excitatorycircularmusclemotorneurons(12%)Inhibitorycircularmusclemotorneurons
8、(16%)(8)Descendinginterneuronslocalreflex(5%)(9)Descendinginterneurons(2%):secretomotorreflex(10)DescendingMMCinterneurons(4%)6LM:longitudinalmuscle;MP:myentericplexus;CM:circularmuscle;SM:submucosalplexus;Muc:mucosaSubmucosalNeurons(11)Submuc
