原发性支气管肺癌中英文对照ppt课件.ppt

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1、原发性支气管肺癌Primarybronchogeniccarcinoma呼吸内科RespiratoryDepartment熊维宁Xiong,Weining1定义Definition原发性支气管肺癌简称肺癌，是起源于支气管粘膜或腺体的肿瘤。Primarybronchogeniccarcinomaisabbreviatedtolungcancer,itderivesfrombronchimucosaorgland.2EpidemiologyLungCancerWorldwide:mostcommoncancer2,000,000casesperyearChina:first

2、leadingcauseofcancerdeathinurbanarea<15%5-yearsurvival3病因和发病机制Etiologyandpathogenesis1吸烟1Smoking4LungCancer:SmokingFactsTobaccouseistheleadingcauseoflungcancer87%oflungcancersarerelatedtosmokingRiskrelatedto:AmountsmokedAgeofsmokingonsetProductsmoked(tar/nicotinecontent,filters)Depthofin

3、halationGenderRiskgoesdownafter>5yrscessationAt15years,80-90%riskreductionNevergetsto“neversmoker”risk520YearLag6Ifwhathappenedonyourinsidehappenedonyouroutside,wouldyoustillsmoke?72职业致癌因子2Occupationcarcinogenicfactor:Asbestos,Radon3空气污染3Airpollution（1）室外大环境污染（1）Outdoorenvironmentpolluti

4、on（2）室内小环境污染（2）Indoorenvironmentpollution4电离辐射4Ionizingradiation85饮食与营养5DietandnutritionVITAMINA???????????????????96其他因素6Otherfactors7遗传因素7HereditaryfactorTumorsuppressorgenes*p53Dominantoncogenes*Kras*Her-2/neu10病理和分类Pathologyandclassification11解剖学分类Anatomyclassification1中央型肺癌1Centrall

5、ungcancer122周围型肺癌2Peripherallungcancer13组织学分类Histologyclassification1小细胞肺癌1Smallcelllungcancer,SCLC（1）燕麦细胞型（1）oatcelltype（2）中间细胞型（2）intermediatecelltype（3）混合型（3）mixedtype14SmallcellcarcinomaRareinnon-smokersLargehilarmass70%presentwithovertmetastasisVerychemo-responsive…Worstprognosis15S

6、mallcellcarcinoma162非小细胞肺癌2Non-smallcelllungcancer,NSCLC（1）鳞状细胞癌（鳞癌）（1）Squamouscellcarcinoma,SCC（2）腺癌和支气管肺泡癌（2）Adenocarcinoma，AC，andbronchoalveolarcarcinoma（3）大细胞癌（3）Largecellcarcinoma（4）鳞腺癌（4）Adeno-squamouscarcinoma17SquamouscellcarcinomaNow2ndmostcommon(1stinChina)Stronglylinkedwithsmo

7、king60-80%intheproximalairways(centraltype)CavitationTendencytospreadlocally/regionallyPrognosisslightlybetterthanAdenocarcinoma18SquamousCellCarcinoma19SquamousCellCarcinoma20鳞癌21LungCancerPathologyAdenocarcinomaMostcommonpathology(2ndinChina)“Non-smoker’slungcancer”Wome