原发性支气管肺癌中英文对照

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1、1原发性支气管肺癌Primarybronchogeniccarcinoma呼吸内科RespiratoryDepartment熊维宁Xiong,Weining2定义Definition原发性支气管肺癌简称肺癌，是起源于支气管粘膜或腺体的肿瘤。Primarybronchogeniccarcinomaisabbreviatedtolungcancer,itderivesfrombronchimucosaorgland.3EpidemiologyLungCancerWorldwide:mostcommoncancer2,000,000casesperyear

2、China:firstleadingcauseofcancerdeathinurbanarea<15%5-yearsurvival4病因和发病机制Etiologyandpathogenesis1吸烟1Smoking5LungCancer:SmokingFactsTobaccouseistheleadingcauseoflungcancer87%oflungcancersarerelatedtosmokingRiskrelatedto:AmountsmokedAgeofsmokingonsetProductsmoked(tar/nicotinecont

3、ent,filters)DepthofinhalationGenderRiskgoesdownafter>5yrscessationAt15years,80-90%riskreductionNevergetsto“neversmoker”risk620YearLag7Ifwhathappenedonyourinsidehappenedonyouroutside,wouldyoustillsmoke?82职业致癌因子2Occupationcarcinogenicfactor:Asbestos,Radon3空气污染3Airpollution（1）室外大环

4、境污染（1）Outdoorenvironmentpollution（2）室内小环境污染（2）Indoorenvironmentpollution4电离辐射4Ionizingradiation95饮食与营养5DietandnutritionVITAMINA???????????????????106其他因素6Otherfactors7遗传因素7HereditaryfactorTumorsuppressorgenes*p53Dominantoncogenes*Kras*Her-2/neu11病理和分类Pathologyandclassification1

5、2解剖学分类Anatomyclassification1中央型肺癌1Centrallungcancer132周围型肺癌2Peripherallungcancer14组织学分类Histologyclassification1小细胞肺癌1Smallcelllungcancer,SCLC（1）燕麦细胞型（1）oatcelltype（2）中间细胞型（2）intermediatecelltype（3）混合型（3）mixedtype15SmallcellcarcinomaRareinnon-smokersLargehilarmass70%presentwitho

6、vertmetastasisVerychemo-responsive…Worstprognosis16Smallcellcarcinoma172非小细胞肺癌2Non-smallcelllungcancer,NSCLC（1）鳞状细胞癌（鳞癌）（1）Squamouscellcarcinoma,SCC（2）腺癌和支气管肺泡癌（2）Adenocarcinoma，AC，andbronchoalveolarcarcinoma（3）大细胞癌（3）Largecellcarcinoma（4）鳞腺癌（4）Adeno-squamouscarcinoma18Squamous

7、cellcarcinomaNow2ndmostcommon(1stinChina)Stronglylinkedwithsmoking60-80%intheproximalairways(centraltype)CavitationTendencytospreadlocally/regionallyPrognosisslightlybetterthanAdenocarcinoma19SquamousCellCarcinoma20SquamousCellCarcinoma21鳞癌22LungCancerPathologyAdenocarcinomaMos

8、tcommonpathology(2ndinChina)“Non-smoker’slungcancer”Wo