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1、subjectivecognitivedecline主观认知下降ReferenceSunY,YangFC,LinCP,etal.BiochemicalandNeuroimagingStudiesinSubjectiveCognitiveDecline:ProgressandPerspectives.[J].CNSNeuroscience&Therapeutics,2015,21(10):768–775.1.Self-experiencedpersistentdeclineincognitiveco
2、mparedtopreviousstatue.2.Normalage-,gender-,andeducation-adjustedperformanceonstandardizedcognitivetests,whichareusedtoclassifyMCI.SCDＭＣＩmild cognitive impairmentＤementia１２ＳＣＤsubjectivecognitivedecline3Alzheimer’sdisease(50%-75%)DementiaaMCIaMCIischar
3、acterizedbyslightmemoryimpairmentwithrelativepreservationofothercognitivedomains.aMCIisoftenfoundtobeaprodromalstateofAD,presagingsubsequentconversiontoAD.aMCI10-15%ADannualconversionrateSCDdepressionpsychiatricconditionssubstanceabusemedicaldisorders
4、neurologicdiseasemedicationuseSubjectivedeclineinmemory,ratherthanotherdomainsofcognitionOnsetofSCDwithinthelast5yAgeatonsetofSCD≥60yConcerns(worries)associatedwithSCDFeelingofworseperformancethanothersofthesameagegroupIfavailableorpossibletoobtainint
5、herespectivestudy:ConfirmationofcognitivedeclinebyaninformantPresenceoftheAPOEε4genotypeBiomarkerevidenceforAD(definespreclinicalAD)FeaturesthatincreasethelikelihoodofpreclinicalADinindividualswithSCDaccordingtocurrentdata:SCDplus(preclinicalAD)aＭＣＩAD
6、１２ＳＣＤ3CSFBiomarkersInalargerstudy,Visseretal.investigatedtheprevalenceofAD-predictingCSFprofileandcognitiveevolutioninthreegroupsofpatients:SCD,aMCI,andnonamnesticMCI.TheyfoundthattheCSFprofilesofpatientsinallthreegroupswhoshowedsubsequentcognitivedec
7、linewereconsistentwiththeAD-predictingprofiles,withtheseprofilesaremorecommoninthesegroupsthaninhealthycontrols(i.e.,lowAb42andhightaulevels).StructuralMRI1.Thedegreeofatrophyobservedwasrelatedtothemagnitudeofthepatients’self-reportedcognitivecomplain
8、ts.2.SCDpatientshadalesserlefthippocampalvolumethanhealthycontrols.3.VolumetricreductionswerefoundinSCDpatientsthatwereanalogoustochangesobservedinpatientswithaMCI,includingreductionsinmedialtemporalandfrontotemporalregions.DiffusionMRIDiffusi
