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ID:5852247
大小:2.11 MB
页数:63页
时间:2017-12-14
《四、肺部吸入给药系统课件》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、四、肺部吸入给药系统优点:面积,上皮细胞间隙,肺泡、血管和淋巴管,血流速度,无首过破坏、无促进剂系统限制和要求:沉着部位及重现性、长期毒性Inhalationtherapy(Historicalperspective)1955,Metered-doesinhaler(MDI)developedbyGeorgeMaison1956marketed,FDAapprovalMay,1974,Sugarloafconferencemilestoneintheclinicaluseofaerosolizeddrugtherapy1980s-1990s,develo
2、pmentanddeliveryofdrugformulationadditionaldevice,↓oropharyngeallossdrypowderinhaler2000Non-CFCpropellantmedicationsotherthanpulmonarydiseaseInhalationtherapy(Historicalperspective)InhalationforairwaydiseaseLungTotalsurface80M2Majorcontactbetweenbody&environmentHostdefensemechani
3、smhasevolvedtocopewithnoxiousinhaledsubstancesAfewkeyprocessesinasthmapathogenesisaresurfaceprocessesBenefitsofinhalationrouteforairwaydiseaseLunghasmorepotentialsurfaceareaformolecularexchangewithblood&rapidabsorptionActionviaabsorptionthroughtracheobronchialmucosalungparenchyma
4、l(alveolar-capillary)topicallyreactwithreceptorinairwaybothMacromoleculesandAirwayMacromoleculesairwaysurface(3.0M2)nearlyimpermeablelungperiphery(alveoli,80-100M2)dopermeateComparisonoftherapeuticratiousingthreeroutesofadministrationofahypotheticaldrugforequivalenttherapeuticbe
5、nefitsIVOralInhaledunitsavailable1005010toexerteffectreachingtargettissue211reachingothertissues98499therapeuticratio1/491/491/9(effectivedrug/drugactingatothertissue)InhalabledrugforsystemictherapyEfficientlydelivertothelungperipheryReproducibletherapeuticdrugdoseAccommodateflex
6、ibledosingStableformulationatroomTemp.DevicemustbeportableandeasytouseInhalabledrugindustrytodayAtleast5companiesAeroGenAlkermesAradigmcorporationDurapharmaceuticalsInhaleTherapeuticSystemsKnowndevelopinginhalableproteinsAventisBeringα-1proteinaseinhibitorforemphysemaBiogenAVONEX
7、(IFNβ-1a)forMSPfizer,AventisPharmainhalableinsulinMedicalconditionsthatcouldbenefitsfrompulmonarydeliveryPainPanicandanxietyAnaphylaxisCardiacarrhythmiaOtherCVconditionsDiarrheaNauseaandvomitingNicotinewithdrawalUrinaryincontinenceSpasmInsomniaMacromoleculecandidatesforpulmonaryd
8、eliveryInsulinGrowthhormoneAnti-obesityp
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