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ID:34261604
大小:1.89 MB
页数:63页
时间:2019-03-04
《四、肺部吸入给药系统课件》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、四、肺部吸入给药系统优点:面积,上皮细胞间隙,肺泡、血管和淋巴管,血流速度,无首过破坏、无促进剂系统限制和要求:沉着部位及重现性、长期毒性Inhalationtherapy(Historicalperspective)1955,Metered-doesinhaler(MDI)developedbyGeorgeMaison1956marketed,FDAapprovalMay,1974,Sugarloafconferencemilestoneintheclinicaluseofaerosolizeddrugtherapy1980s-1990s,deve
2、lopmentanddeliveryofdrugformulationadditionaldevice,↓oropharyngeallossdrypowderinhaler2000Non-CFCpropellantmedicationsotherthanpulmonarydiseaseInhalationtherapy(Historicalperspective)InhalationforairwaydiseaseLungTotalsurface80M2Majorcontactbetweenbody&environmentHostdefensemec
3、hanismhasevolvedtocopewithnoxiousinhaledsubstancesAfewkeyprocessesinasthmapathogenesisaresurfaceprocessesBenefitsofinhalationrouteforairwaydiseaseLunghasmorepotentialsurfaceareaformolecularexchangewithblood&rapidabsorptionActionviaabsorptionthroughtracheobronchialmucosalungpare
4、nchymal(alveolar-capillary)topicallyreactwithreceptorinairwaybothMacromoleculesandAirwayMacromoleculesairwaysurface(3.0M2)nearlyimpermeablelungperiphery(alveoli,80-100M2)dopermeateComparisonoftherapeuticratiousingthreeroutesofadministrationofahypotheticaldrugforequivalentthera
5、peuticbenefitsIVOralInhaledunitsavailable1005010toexerteffectreachingtargettissue211reachingothertissues98499therapeuticratio1/491/491/9(effectivedrug/drugactingatothertissue)InhalabledrugforsystemictherapyEfficientlydelivertothelungperipheryReproducibletherapeuticdrugdoseAccom
6、modateflexibledosingStableformulationatroomTemp.DevicemustbeportableandeasytouseInhalabledrugindustrytodayAtleast5companiesAeroGenAlkermesAradigmcorporationDurapharmaceuticalsInhaleTherapeuticSystemsKnowndevelopinginhalableproteinsAventisBeringα-1proteinaseinhibitorforemphysema
7、BiogenAVONEX(IFNβ-1a)forMSPfizer,AventisPharmainhalableinsulinMedicalconditionsthatcouldbenefitsfrompulmonarydeliveryPainPanicandanxietyAnaphylaxisCardiacarrhythmiaOtherCVconditionsDiarrheaNauseaandvomitingNicotinewithdrawalUrinaryincontinenceSpasmInsomniaMacromoleculecandidate
8、sforpulmonarydeliveryInsulinGrowthhormoneAnti-obesityp
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