蓖麻籽脱脂提取物对小鼠离体子宫平滑肌的影响.pdf

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1、·5O·ChineseJournaIofInformationonTCMMay2014VoI．21No．5蓖麻籽脱脂提取物对小鼠离体子宫平滑肌的影响苏雅拉图’一，陈宇杰，穆莎茉莉，王立异’，冯景涛，黄凤兰1．内蒙古民族大学生命科学学院，内蒙古通辽028000；2．内蒙古自治区高校蓖麻产业工程研究中心，内蒙古通辽028000摘要：目的确定蓖麻籽中除蓖麻油之外还有一种物质能够引起小鼠子宫平滑肌收缩异常，为进一步研究提供依据。方法采用石油醚脱脂法获得蓖麻籽脱脂提取物，提取物分为4、8、l6、32h4个时间组和

2、O．15、O．06、0．02mg／mL3个剂量组，以小鼠离体子宫平滑肌肌张力和收缩周期为指标，观察提取物存放时间和浓度对小鼠离体子宫平滑肌的影响。结果与对照组比较，提取物4、8、16h组能显著增强离体子宫平滑肌肌张力(P

3、

4、actofCastorBeanonSmoothMuscleofIsolatedMouseUterusSUYa-latu一，CHENYu~ie’一，MUSha．moli。，WANGLi．yi，FENGJing．tao，HUANGFeng．1rdn，．CollegeofL啦SciencesInnerMongoliaUniversityfortheNationalities,Tongliao028000,China：2．InnerMongoliaIndustrialEngineeringResearchCen

5、terofUniversitiesforCastor,Tongliao028000,China)Abstract：ObjectiveTodeterminethatinthecastorbeanbesidescastoroilthereisanothersubstancethatcarlcausetheabnormalcontractionofthesmoothmuscleofthemouseuterus，andconsequentlyprovidethebasisforfurtherresearch．M

6、ethodsThedefattedextractofcastorbeanwasobtainedbypetroleumetherdegreasing，takingthetensionandthecontractioncycleofthesmoothmuscleofisolatedmouseuterineasindices，theeffectofthestoragetimeandconcentrationoftheextractonthesmoothmuscleofisolatedmouseuteruswe

7、reobserved．ResultsComparedwiththecontrolgroup，groupswiththestoragetimeoftheextract4，8，16hcouldsignificantlyenhancethetensionofthesmoothmuscleofisolatedmouseuterus(P<0．05，P<0．01)，4，8，16and32hgroupcouldsignificantlydecreasethecontractioncyclerespectively(P

8、0．05)．0．15，0．06and0．02mg／mLgroupcouldsignificantlydecreasethe