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时间:2020-05-07
《双歧杆菌三联活菌胶囊对肝硬化非感染性腹泻患者细胞免疫功能的影响及疗效观察-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、论著·中国现代医生2014年4月第52卷第10期双歧杆菌三联活菌胶囊对肝硬化非感染性腹泻患者细胞免疫功能的影响及疗效观察张天晓向圆花。1.浙江省苍南县人民医院感染科,浙江苍南325800;2.浙江省台州医院路桥院区内科,浙江台州318050【摘要】目的探讨口服双歧杆菌三联活菌胶囊对肝硬化非感染性腹泻患者细胞免疫功能的影响及临床疗效。方法将80例肝硬化非感染性腹泻随机分为观察组和对照组。两组均予以抗病毒、护肝、利尿和营养支持等治疗,观察组加用双歧杆菌三联活菌胶囊420mg/次,2次/d,连用4周。结果治疗4周后,两
2、组AIJT、AST和TBIL水平均明显下降(P<0.05或P<0.01),且观察组下降幅度大于对照组(P<0.05);同时观察组CD4水平及CD4+/CD8比值明显升高(P<0.05),CD8水平较前无明显变化(P>0.05);观察组临床总有效率(92.5%)明显高于对照组(72.5%)(x=5.54,P<0.05)。结论双歧杆菌三联活菌胶囊用于肝硬化非感染性腹泻治疗取得了良好疗效,能明显改善患者肝功能。增强细胞免疫功能。【关键词】肝硬化;腹泻;双歧杆菌三联活茵胶囊;细胞免疫【中图分类号】R575.2【文献标识码
3、】A[文章编号】1673—9701(2014)10-0004—03Influenceandefectofbifidtripleviablecapsuleoncellularimmunefuncti0n0fpatientswithcirrhosisnoninfectiOUSdiarrheaZHANG死anxiaoXIANGYuanhua?1.InfectiousDiseaseDepartment,CangnanPeople’SHospitalinZhejiangProvince,Cangnan325800,Chin
4、a;2.Depart-mentofMedicine,LuqiaoHospitalofTaizhouPeople’SHospitalinZhejiangProvince,Taizhou318050,China【Abstract】0bjectiveTodiscusstheinfluenceandeffectofbifidtripleviablecapsuleoncellularimmunefunctionofpatientswithcirrhosisnoninfectiousdiarhea.MethodsAtotal
5、of80casesofpatientswithcirrhosisnoninfectiousdi-arrheawereselectedanddividedintoobservationgroupandcontrolgroupatrandom.Thepatientsintwogroupsweregivenanti—virus,liverprotection,diuresis,nutritionsupportandetc.Thepatientsinobservationgroupwereadditionallygive
6、nbifidtripleviablecapsule420mgpertimetwiceadayfor4weeks.ResultsAftertreatmentfor4weeks,ALT,ASTandTBILlevelsofpatientsintwogroupsdeclinedobviouslythanbefore(P<0.05orP<0.01),andthedecliningrateofpatientsinobservationgroupwasmuchhigherthanthatincontrolgroup(尸l<0
7、.05).Meanwhile,CD4levelandCD4+/CD8ratioofpatientsinobservationgroupobviouslyrose(P<0.05),andCD8levelappearednoobviouschangethanbe—fore(尸>0.05),theCD8levelsaftermedicaltreatmentappearednoobviouschanges.Thetotalclinicaleficiencyofpa—tientsinobservationgroupwas9
8、2.5%,whichwasmuchhigherthanthatincontrolgroup(72.5%)(x=5.54,P
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