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时间:2020-05-07
《ARFI、Forns指数、FIB-4和APRI无创诊断慢性乙型病毒性肝炎肝纤维化的研究-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、l8·论著·中国肝脏病杂志(电子版)》2014年第6卷第1期ARFI、Foms~数、皿一4和无创诊断慢性乙型病毒陛肝炎肝纤维化的研究刘京,一,刘映霞,董常峰,姚思敏,李莎茜,袁静,陈川铁,赵美芬,林益敏,彭忠田。(1.深圳市第三人民医院感染科,感染性疾病国家重点学科,广东深圳518112;2.南华大学第一临床学院感染科,湖南衡阳421001)摘要:目的声辐射力脉冲成像技术(ARFI)及血清学诊断模型(Forns~数、FIB一4、APRI)对慢性乙型病毒性肝炎肝纤维化评估的价值。方法111例确诊为慢性乙型病毒性
2、肝炎患者,根据肝组织活检病理分期结果分组:无明显肝纤维化组(S。、S。)40例,明显肝纤维化组(≥S)48例、早期肝硬化组(S)23例。每例患者同期进行ARFI、Forns指数、FIB.4、APRI的评估。比较无创诊断模型与肝脏病理的相关性,并根据受试者工作特征曲线(ROC)分析无创诊断模型对肝纤维化的诊断价值。结果ARFI、Forns指数、FIB.4、APRI4种无创诊断方法与肝组织活检具有良好的一致性,其皮尔逊相关系数(Pearsoncorrelationcoeficient)分别为0,882、O,639
3、、0。589、0.418。明显肝纤维化组(≥s2)及早期肝硬化组,ARFI的诊断价值均优于FIB.4(z=2.882,P=0.004;Z=3.215,P=O.001)、APRI(z:4.850,P4、sliverfibrosisinpatientswithchronicliverdiseasesLIUJing,LIUYing—xia,D0NGChang.feng,YA0Si.min‘LISha—xi,YUANJing,CHENChuan—tie,,ZHAOMei—fen,LINYi-min,PENGZhong—tian.DepartmentofInfectiousDiseases,fPeopleHospitalofShenzhen,Shenzhen518112,China,"2.DepartmentofI5、nfectiousDiseases,theFirstAffiliatedHospitalofNanhuaUniversity,Hengyang42iooi.ChincI)Abstract:0bjectiveToassessmentthevalueofacousticradiationforceimpulse(ARFI)andserologicaldiagnosismodel(Foresindex.FIB.4.APRI)toliverfibrosisofchronichepaticB.MethodsT0talo6、fl11patientconfirmedasCHB,dividedintogroupsaccordingtotheresultoftheliverbiopsy:nosignificantliverfibrosisgroup(S0,S1)4Ocases,significantlyfibrosisgroup(≥S2)48cases,earlycirrhosisgroup(S4)23cases.Duringthesameperiod,eachpatientwiththeassessmentofARFI,Fornsi7、ndex,Fib-4andAPRI.Comparedthecorrelationofnoninvasivediagnosismodelandliverbiopsy.Moreover,analysisthediagnosticvalueofnoninvasiveliverfibrosismodeltotheliverfibrosisaccordingtothereceiver-operatingcharacteristicCHIVe.ResultsARFI,Foresindex,FIB一4,APRI,thefo8、urkindsofnoninvasivediagnosticmethodhasagoodconsistencywithliverbiopsy,andtheirPearsoncorrelationcoefficientwere0.882,0.639,0.589,0.418.TheassessmentvalueofARFItosignificantlyfibrosisgroup(≥S2)wassuper
4、sliverfibrosisinpatientswithchronicliverdiseasesLIUJing,LIUYing—xia,D0NGChang.feng,YA0Si.min‘LISha—xi,YUANJing,CHENChuan—tie,,ZHAOMei—fen,LINYi-min,PENGZhong—tian.DepartmentofInfectiousDiseases,fPeopleHospitalofShenzhen,Shenzhen518112,China,"2.DepartmentofI
5、nfectiousDiseases,theFirstAffiliatedHospitalofNanhuaUniversity,Hengyang42iooi.ChincI)Abstract:0bjectiveToassessmentthevalueofacousticradiationforceimpulse(ARFI)andserologicaldiagnosismodel(Foresindex.FIB.4.APRI)toliverfibrosisofchronichepaticB.MethodsT0talo
6、fl11patientconfirmedasCHB,dividedintogroupsaccordingtotheresultoftheliverbiopsy:nosignificantliverfibrosisgroup(S0,S1)4Ocases,significantlyfibrosisgroup(≥S2)48cases,earlycirrhosisgroup(S4)23cases.Duringthesameperiod,eachpatientwiththeassessmentofARFI,Fornsi
7、ndex,Fib-4andAPRI.Comparedthecorrelationofnoninvasivediagnosismodelandliverbiopsy.Moreover,analysisthediagnosticvalueofnoninvasiveliverfibrosismodeltotheliverfibrosisaccordingtothereceiver-operatingcharacteristicCHIVe.ResultsARFI,Foresindex,FIB一4,APRI,thefo
8、urkindsofnoninvasivediagnosticmethodhasagoodconsistencywithliverbiopsy,andtheirPearsoncorrelationcoefficientwere0.882,0.639,0.589,0.418.TheassessmentvalueofARFItosignificantlyfibrosisgroup(≥S2)wassuper
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