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时间:2020-04-27
《十枣汤对肺纤维化大鼠血清TNF-α和TGF-β1浓度的影响-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、第12卷第8期·总第184期2014年4月·下半月刊现代远程教育}∞D£勰D嚣驰H0E目)u0心oFC晰十枣汤对肺纤维化大鼠血清TNF-~和TGF-~浓度的影响※宋启兰王燕青王宁(1青岛大学医学院,青岛266021;2山东省青岛市海慈医疗集团,青岛266033)摘要:目的通过检测博莱霉素所致肺纤维化大鼠血清中肿瘤坏死因子一q(TNF-和转化生长因子一&(TGF-~)浓度,探讨十枣汤对肺纤维化大鼠的治疗作用及疗效机制。方法108只雄性健康V6star大鼠随机分为6组:空白对照、模型对照、强的松、十枣汤
2、低剂量、十枣汤中剂量、十枣汤高剂量组,每组18只。空白对照组以气管内注入生理盐水的方法设立对照,余各组气管内注入博莱霉素建立肺纤维化模型,遣模第2天始进行药物干预,第14天、28天各处死9只大鼠,采集血清,取右肺,光镜下观察肺组织病理变化,ELISA法检测血清中肌a和TGF-~浓度。结果给药后第14、28天,与空白时照组相比,模型对照组出现典型肺纤维化改变,血清僻d和僻BI的浓度明显升高(P3、n05),与十枣汤中剂量组血清中TGF-~浓度无显著差异(P>O.05);28天时,强的松组大一哼鼠血清TNF-q含量较十枣汤低剂量组低,有显著差异(P<0.05),与十枣汤中剂量组无显著差异(P>n05);强的松组与十枣汤低剂量组大鼠血清中TGF-131浓度无显著性差异(P>0.05),十枣汤中剂量组比强的松组大鼠血清中T4、GF-~低,有显著差异(P<0.05)。结论十枣汤可减轻博来霉素所致肺纤维化大鼠血清中1NF_d、TGF-I~的含量,延缓肺纤维化进展,减轻肺纤维化程度。关键词:肺纤维化;十枣汤;大鼠;肿瘤坏死因子-a;转化生长因子一Bl;实验研究doi:10.3969/j.issrr1672-2779.2014.08.100文章编号:1672—2779(2014)一08-0157—03TheEffeCtofshi盈ot薯n譬onSen巾TNFn翻1dTGF-p1.evel~aandTGF-pLevelsinrat5、swithPuImonary同broslsRatsqilan'WangYanq毗WangNing(1QingdaoUniversityMedialCo~ge,QingDao266021,China;2Q卿Dao'frMedialgroup,qingDao266033,China,China)Al,stract:ObjectiveToassesstheefficacyandmechanismofShizao风inthetreatmentofpulmonaryfibrosisinratsthroughd6、etectingthelev—elsofserumTumornecrosisactor-alpha(TNF-~)andTransforminggrowthfactorbetal(TGF-~).M吼lmds108maleWistarratswereequallyrandomizedtosixgroupsasnormalcontrol,modelcontrol,predrfisone,ShizaoTanglowdose,ShizaoTangmiddledose,ShisaoTanghighdose.No7、rmalcontrolgroupwasgiveI1normalsalineinstead,whiletherestofthe5groupsinducedpulmonaryfibrosiswithbleomycinendotracheallyCorrespondingdrugsweregiventhenextdayuponcompletionofthemode1.After14and28daysofmedication,9ratsineachgroupweresac—.rificedrespectiv8、ely.Thepathologyof1ungtissuewasobservedmicroscopically.SerumsampleswerecollectedforTNF_aandTGF-~detectionbyELLISResultsComparedwithnormalcontrolgroup,thelungtissueinthemodelcontrolgroupshowedobviouspulmonaryalveolitisandfi—bmsis.andthel
3、n05),与十枣汤中剂量组血清中TGF-~浓度无显著差异(P>O.05);28天时,强的松组大一哼鼠血清TNF-q含量较十枣汤低剂量组低,有显著差异(P<0.05),与十枣汤中剂量组无显著差异(P>n05);强的松组与十枣汤低剂量组大鼠血清中TGF-131浓度无显著性差异(P>0.05),十枣汤中剂量组比强的松组大鼠血清中T
4、GF-~低,有显著差异(P<0.05)。结论十枣汤可减轻博来霉素所致肺纤维化大鼠血清中1NF_d、TGF-I~的含量,延缓肺纤维化进展,减轻肺纤维化程度。关键词:肺纤维化;十枣汤;大鼠;肿瘤坏死因子-a;转化生长因子一Bl;实验研究doi:10.3969/j.issrr1672-2779.2014.08.100文章编号:1672—2779(2014)一08-0157—03TheEffeCtofshi盈ot薯n譬onSen巾TNFn翻1dTGF-p1.evel~aandTGF-pLevelsinrat
5、swithPuImonary同broslsRatsqilan'WangYanq毗WangNing(1QingdaoUniversityMedialCo~ge,QingDao266021,China;2Q卿Dao'frMedialgroup,qingDao266033,China,China)Al,stract:ObjectiveToassesstheefficacyandmechanismofShizao风inthetreatmentofpulmonaryfibrosisinratsthroughd
6、etectingthelev—elsofserumTumornecrosisactor-alpha(TNF-~)andTransforminggrowthfactorbetal(TGF-~).M吼lmds108maleWistarratswereequallyrandomizedtosixgroupsasnormalcontrol,modelcontrol,predrfisone,ShizaoTanglowdose,ShizaoTangmiddledose,ShisaoTanghighdose.No
7、rmalcontrolgroupwasgiveI1normalsalineinstead,whiletherestofthe5groupsinducedpulmonaryfibrosiswithbleomycinendotracheallyCorrespondingdrugsweregiventhenextdayuponcompletionofthemode1.After14and28daysofmedication,9ratsineachgroupweresac—.rificedrespectiv
8、ely.Thepathologyof1ungtissuewasobservedmicroscopically.SerumsampleswerecollectedforTNF_aandTGF-~detectionbyELLISResultsComparedwithnormalcontrolgroup,thelungtissueinthemodelcontrolgroupshowedobviouspulmonaryalveolitisandfi—bmsis.andthel
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