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时间:2020-04-19
《非霍奇金淋巴瘤患者血清β2-微球蛋白和CA125检测的意义.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、中国当代医药2014年8月第21卷第23期·临床研究非霍奇金淋巴瘤患者血清132一微球蛋白和CA125检测的意义张浩然翟云芝楼建军z孙惠娟,1.蚌埠医学院第一附属医院肿瘤内科,安徽蚌埠233004;2.蚌埠医学院第一附属医院放疗科,安徽蚌埠233004【摘要】目的探讨非霍奇金淋巴瘤(NHL)患者血清pr微球蛋白(132-MG)和CA125检测的临床意义。方法检测76例NHL患者及32例体检健康者的血清pMG和CA125水平,分析B:一MG和CA125与疾病临床进展及预后的关系。结果NHL患者血清B厂MG和CA125水平高于健康体检者(P<0.05);132-MG和CA12
2、5水平与患者年龄和性别均无相关性(尸>0.05);侵袭性和高侵袭性淋巴瘤患者的B一MG和CA125水平比惰性淋巴瘤患者高(P<0.05);11~IV期比I~Ⅱ期患者的p2一MG和CA125水平高(P<0.05);患者经2个周期化疗后p2一MG和CA125的水平较治疗前下降(P<0.05)。结论血清B一MG和CA125水平检测可作为NHL诊断、疾病恶性程度、分期、疗效评估的参考指标。[关键词】非霍奇金淋巴瘤;B一微球蛋白;CA125抗原【中图分类号】R557+.4[文献标识码】A[文章编号】1674—4721l2014)08(b)一0051-03Significanceof
3、determinationofserumIjI2一MGandCA125inpatientswithnon-HodgkinlymphomaZHANGHao-ranlZHAIYun-zhilLOUJian-jun2SUNHui-juanl1.DepartmentofMedicalOncology,theFirstAffiliatedHospitalofBengbuMedicalCollege,Bengbu233004,China;2.DepartmentofRadiationOncology,theFirstAffiliatedHospitalofBengbuMedicalC
4、ollege,Bengbu233004,China[Abstract】ObjectiveToinvestigatetheclinicalsignificanceoftheselMmB2一MGandCA125innon-Hodgkinlym-phoma(NHL).MethodsThelevelofserumprMGandCA125in76patientswithNHL(NHLgroup)and32healthysubjects(controlgroup)weredetected.Therelationshipsbetweenthemandclinicalcharacteri
5、sticsandprognosiswereexplored.ResultsThelevelsofserumBrMGandCA125inNHLgroupwereobviouslyhigherthanthoseinthecontrolgroup<0.05).ThelevelsofserumB2一MGandCA125inNHLgroupwerenotsignificantlycorrelatedwithageandgenderC尸>0.05).ThelevelsofserumprMGandCA125inaggressiveandhigh-aggressiveNHLwereobv
6、iouslyhigherthanthoseinindolentNHL(尸0.05).Thelevelsofserl/mB2一MGandCA125innl—IVstagewereobviouslyhigherthanthoseinI—IIstage(P<0.05).ThelevelsofserumB2一MGandCA125weresignificantlydecreasedaftertwocyclesofchemotherapyrP<0.05).ConclusionThelevelsofserum132-MGandCA125canbetakenasreferenceinde
7、xfordiag·nosis,invasiveness,classification,effectivenessoftreatmentinthepatientswithNHL.【Keywords]Non—Hodgkinlymphoma(NHL);132-microglobulin(132-MG);Carbohydrateantigen125(CA125)非霍奇金淋巴瘤(non—Hodgkinlymphoma,NHL)antigen125。CA125)的水平可能与大部分NHL的治疗是淋巴瘤中最为常见的类型,而近年来淋巴瘤的发病效
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