非霍奇金淋巴瘤患者血清β2-微球蛋白和CA125检测的意义-论文.pdf

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1、中国当代医药2014年8月第21卷第23期·临床研究非霍奇金淋巴瘤患者血清132一微球蛋白和CA125检测的意义张浩然翟云芝楼建军z孙惠娟，1．蚌埠医学院第一附属医院肿瘤内科，安徽蚌埠233004；2．蚌埠医学院第一附属医院放疗科，安徽蚌埠233004【摘要】目的探讨非霍奇金淋巴瘤(NHL)患者血清pr微球蛋白(132-MG)和CA125检测的临床意义。方法检测76例NHL患者及32例体检健康者的血清pMG和CA125水平，分析B：一MG和CA125与疾病临床进展及预后的关系。结果NHL患者血清B厂MG和

2、CA125水平高于健康体检者(P<0．05)；132-MG和CA125水平与患者年龄和性别均无相关性(尸>0．05)；侵袭性和高侵袭性淋巴瘤患者的B一MG和CA125水平比惰性淋巴瘤患者高(P<0．05)；11～IV期比I～Ⅱ期患者的p2一MG和CA125水平高(P<0．05)；患者经2个周期化疗后p2一MG和CA125的水平较治疗前下降(P<0．05)。结论血清B一MG和CA125水平检测可作为NHL诊断、疾病恶性程度、分期、疗效评估的参考指标。[关键词】非霍奇金淋巴瘤；B一微球蛋白；CA125抗原【中

3、图分类号】R557+．4[文献标识码】A[文章编号】1674—4721l2014)08(b)一0051-03SignificanceofdeterminationofserumIjI2一MGandCA125inpatientswithnon-HodgkinlymphomaZHANGHao-ranlZHAIYun-zhilLOUJian-jun2SUNHui-juanl1．DepartmentofMedicalOncology，theFirstAffiliatedHospitalofBengbuMedica

4、lCollege，Bengbu233004，China；2．DepartmentofRadiationOncology，theFirstAffiliatedHospitalofBengbuMedicalCollege，Bengbu233004，China[Abstract】ObjectiveToinvestigatetheclinicalsignificanceoftheselMmB2一MGandCA125innon-Hodgkinlym-phoma(NHL)．MethodsThelevelofserum

5、prMGandCA125in76patientswithNHL(NHLgroup)and32healthysubjects(controlgroup)weredetected．Therelationshipsbetweenthemandclinicalcharacteristicsandprognosiswereexplored．ResultsThelevelsofserumBrMGandCA125inNHLgroupwereobviouslyhigherthanthoseinthecontrolgrou

6、p<0．05)．ThelevelsofserumB2一MGandCA125inNHLgroupwerenotsignificantlycorrelatedwithageandgenderC尸>0．05)．ThelevelsofserumprMGandCA125inaggressiveandhigh-aggressiveNHLwereobviouslyhigherthanthoseinindolentNHL(尸0．05)．Thelevelsofserl／mB2一MGandCA125innl—IVstagew

7、ereobviouslyhigherthanthoseinI—IIstage(P<0．05)．ThelevelsofserumB2一MGandCA125weresignificantlydecreasedaftertwocyclesofchemotherapyrP<0．05)．ConclusionThelevelsofserum132-MGandCA125canbetakenasreferenceindexfordiag·nosis，invasiveness，classification，effectiv

8、enessoftreatmentinthepatientswithNHL．【Keywords]Non—Hodgkinlymphoma(NHL)；132-microglobulin(132-MG)；Carbohydrateantigen125(CA125)非霍奇金淋巴瘤(non—Hodgkinlymphoma，NHL)antigen125。CA125)的水平可能与大部分NHL的治疗是淋巴瘤中最为常见的类型，而近年来淋巴瘤的发病效