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1、清开灵注射液治疗CAP的临床疗效及其PCT和CRP的影响[摘要]冃的观察清开灵注射液治疗社区获得性肺炎(CAP)的临床效果,探讨其对CAP患者血清降钙素原(PCT)和C反应蛋白(CRP)的影响。方法60例CA卩患者随机分为治疗组和对照组。对照组采用抗生素对症治疗,治疗组另给予清开灵注射液,两组疗程均为14d0治疗结束后评价临床疗效、观察治疗前后卩CT和CRP水平的改变。结果治疗组临床疗效有效率为96.7%,对照组为76.7%,两组相比较有显著性差异(P<0.05);治疗后,治疗组血清PCT、CRP水平与治疗前和对照组比较显著下降,相比较有显著性差异(P<0.05);治疗组不良反应发生率为
2、13.3%,对照组不良反应发生率为70.0%,两组比较有显著性差异(PV0.05)。结论清开灵注射液能有效抑制CAP患者的炎症反应,且安全、有效,值得临床推广应用。[关键词]社区获得性肺炎;清开灵注射液;降钙素原;C反应蛋白[中图分类号]R259;R563.1[文献标识码]B[文章编号]1673-9701(2011)26-75-02ClinicalEfficacyofQingkailingInjectioninTreatmentofCommunity一Acquired卩neumoniaandImpactonSerum卩rocalcitoninandC-reactiveProteinXUX
3、uefenglHOUQixia21.XishidianCommunityHealthServiceStationofZhujiRedCrossHospital,Zhuji311800,China;2.FirstDepartmentofTnternalMedicine,ZhujiRedCrossHospital,Zhuji311800,China[Abstract]ObjectiveToobservetheclinicalefficacyofqingkailinginjectionintreatmentofcominunity-acquiredpneumonia(CAP)andimpact
4、onserumprocalcitonin(卩CT)andC-reactiveprotein(CRP)・MethodsSixtycasesofpatientswithCAPwererandomlydividedintotreatmentgroupandcontrolgroup.Thecontrolgroupwasgivensymptomatictreatmentofantibioticsandthetreatment,groupwasgivenassistedtreatmentofqingkailinginjection.Thetwogroupsweretreatedfor14days.A
5、ftertreatment,theclinicalefficacywasevaluated:Pre-treatmentandaftertreatment,thePCTandCRPlevelsoftwogroupswereobserved.ResultsTheclinicaltotaleffectiverateofthetreatmentgroupwas96.7%,anditwassignificantlyhigherthanthatofthecontrolgroup(76.7%)withsignificantdifference(PVO.O5);Aftertreatment,thePCT
6、andCRPlevelsoftreatmentgroupdecreased,andcomparedwiththepre-treatmentandthecontrolgroup,thedifferencesweresignificant(卩VO.05)•Theincideneerateofadversereactionsoftreatmentgroupwas13.3%,anditwassignificantlylowerthanthatofthecontrolgroup(70.0%)withsignificantdifference(P<0.05)・ConclusionQingkailin
7、ginjectioncaneffectivelyinhibittheinf1且minatoryresponseofpatientswithCAP,anditissafe,effectiveandworthyofclinicalapplication.[Keywords]Community-acquiredpneumonia;Qingkailinginjection;Procalcitonin;C-reactiveprotein肺炎是