海昆肾喜联合渴络欣治疗糖尿病肾病的疗效观察_李瑜琳.pdf

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1、·2124·辽宁中医杂志2014年第41卷第10期DOI∶10．13192/j．issn．1000-1719．2014．10．041海昆肾喜联合渴络欣治疗糖尿病肾病的疗效观察李瑜琳(青海省人民医院肾内科，青海西宁810001)摘要:目的:探讨海昆肾喜联合渴络欣治疗糖尿病肾病的临床疗效。方法:按照数字随机分组法将本院收治的252例DN患者均分为联合组、海昆肾喜组和渴络欣组，在常规糖尿病治疗基础上，联合组给予海昆肾喜联合渴络欣治疗，海昆肾喜组仅给予海昆肾喜治疗，渴络欣组仅给予渴络欣治疗，比较3组患者临床疗效及治疗前、后FBG、TG、TC、LDL-C、HDL-

2、C、BUN、Scr、mAlb、UTP变化情况。结果:联合组患者治疗显效率及总有效率均明显高于海昆肾喜组和渴络欣组，差异均具有显著性(P＜0.05);3组患者治疗后FBG未发生明显变化，均在7．8mmol/L以下;3组患者治疗后TG、TC、LDL-C和HDL-C均发生明显变化，与治疗前比较，差异均具有显著性(P＜0.05);联合组患者治疗后TG、TC和LDL-C均明显低于海昆肾喜组和渴络欣组，HDL-C明显高于海昆肾喜组和渴络欣组，差异均具有显著性(P＜0.05);3组患者治疗后BUN、Scr、mAlb和UTP均明显降低，与治疗前比较，差异均具有显著性(P

3、＜0.05);联合组患者治疗后BUN、Scr、mAlb和UTP均明显低于海昆肾喜组和渴络欣组，差异均具有显著性(P＜0.05)。结论:海昆肾喜联合渴络欣治疗糖尿病肾病可达到优势互补的效果，延缓肾功能损伤疗效显著，无不良反应，临床应用和推广价值较高。关键词:海昆肾喜;渴络欣;糖尿病肾病;疗效中图分类号:Ｒ587．1文献标志码:B文章编号:1000-1719(2014)10-2124-03EfficacyofHaikunShenxiwithKeluoxininTreatmentofDiabeticNephropathyLIYulin(Nephrology，Q

4、inghaiProvincialPeople'sHospital，Xi'ning810001，Qinghai，China)Abstract:Objective:ToinvestigatethetherapeuticeffectofHaikunShenxiwithKeluoxininthetreatmentofdiabeticnephrop-athy．Methods:252caseswithDNwererandomlydividedintocombinationtherapygroup，HaikunShenxigroupandKeluoxingroup．O

5、nthebasesofconventionaltherapy，combinationtherapygroupwastreatedbyHaikunShenxiwithKeluoxin．HaikunShenxigroupwastreatedbyHaikunshenxiandKeluoxingroupwastreatedbyKeluoxin．TheclinicaleffectsandthechangesofFBG，TG，TC，LDL-C，HDL-C，BUN，Scr，mAlbandUTPwerecompared．Ｒesults:Thetreatmenteffic

6、iencyofcombinationtherapygroupwassignificantlyhigherthanthatofHaikunShenxigroupandKeluoxingroup(P＜0.05)．TherewasnoevidentchangeforFBGaftertreatmentanditwasbelow7．8mmol/L．TG，TC，LDL-CandHDL-Cwerequitedifferentaftertreatmentandtherewassignificantdifferenceafterthetreatment(P＜0.05)．T

7、heTG，TCandLDL-ClevelsofcombinationtherapygroupweresignificantlowerthanthoseofHaikunShenxigroupandKeluoxingroup(P＜0.05)．TheBUN，Scr，mAlbandUTPlevelsofthethreegroupsweresignificantlowerthanthosebeforetreatment(P＜0.05)．TheBUN，Scr，mAlbandUTPlevelsofcombinationtherapygroupweresignifica

8、ntlowerthanthoseofHaikunShenxigroupandKe