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1、·6·YoujiangMedicalJournal2005,Vol.33No.1白介素4和17在溃疡性结肠炎发生发展中的作用123梁雄均,马泽,曾雅静(1.广东省阳江市江城区岗列医院内科,广东阳江529500;2.广东省东莞市慢性病防治院皮肤科,广东东莞523000;3.广东省阳江市江城区平冈中心医院内科,广东阳江529500)【摘要】目的探讨白细胞介素24(IL24)和白细胞介素217(IL217)在溃疡性结肠炎(UC)发生发展中的作用。方法采用ELISA法测定40例UC患者及30例正常对照者血浆IL24和IL217的含量。结果40例UC患者和30例健康人血浆
2、IL24(pg/ml)4.57±1.36vs18.67±4.22或IL217浓度(pg/ml)29.4±2.8vs19.1±2.1比较,差异有非常显著性(P<0.01)。活动期(29例)和静止期(11例)UC患者血浆IL24(pg/ml)9.4±1.6vs12.03±3.72或IL217浓度(pg/ml)32.63±3.58vs19.23±2.37比较,差异有非常显著性(P<0.01)。轻、中、重度活动期血浆IL24(pg/ml)分别为13.35±2.98,8.12±1.56,4.4±1.0或IL217浓度(pg/ml)分别为13.36±1.15,19.31±1
3、.78,32.6±3.01相互间比较,差异有显著性(P<0.01)。结论IL24和IL217参与了UC的炎症过程。Th1/Th2细胞免疫的失衡与UC的肠道炎症启动和慢性化相关。【关键词】白细胞介素4;白细胞介素17;溃疡性结肠炎;酶联免疫吸附试验文章编号:1003-1383(2005)01-0006-03中图分类号:R574.62文献标识码:ATheclinicalsignificanceofinterleukin4&interleukin17'sbloodplasmalevelinpatientswithulcerativecolitis123LiangXio
4、ng2jun,MaZe2lin,ZengYa2jing(1.Departmentofmedicine,TheGangLieHospitalofYangjiangCity,529500;2.Dongguanchronicdiseasepreventinghospital,Dongguan,Guangdong523000;3.Departmentofmedicine,ThePinggangHospitalofYangjiangCity,Guangdong529500,)【Abstract】ObjectiveObjectiveToexploretheclinicals
5、ignificanceofinterleukin4(IL4)&interleukin17`sbloodplasmalevelinpatientswithulcerativecolitis(UC).MethodsThebloodplasmalevelofIL24and217werede2tectedbyenzyme2linkedimmunosorbentassay(ELISA)inpatientswithUC.ResultsThebloodplasmalevelofIL4inpatientswithUC(40cases)wassignificantlylowert
6、hanthatinnormalpeople(30cases)[(4.57±1.36)pg/mlvs(18.67±4.22)pg/ml(P<0.01)],andthelevelofIL17wassignificantlyhigherthanthatinnormalpeople[(29.4±2.8)pg/mlvs(19.1±2.1)pg/ml(P<0.01)].Thereweresignificantstatisticaldifferencebetweenactivegroup(29cases)andquiescentgroup(11cases)((P<0.01)b
7、ythebloodplasmalevelofIL24(9.4±1.6vs12.03±3.72pg/ml)orIL217(32.63±3.58vs19.23±2.37pg/ml).Comparingmild,moderateandsevereUC,thebloodplasmalevelofIL24and217weresignicicantlydifferent(P<0.01).ConclusionInterleukin24andInterleukin17participatetheinflammatoryprocedureofUC.ThedisbalanceofT
8、h1/Th2cellim
