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1、解痉通络活血药物对纠正高血压患者氧化应激功能紊乱的临床观察作者：陆高翔，李天资，陆克兴，韦华，罗章伟【摘要】冃的了解解痉通络活血纱物纠止高血压患者氧化应激功能紊乱的改善效果。方法选取76例高血压病患者随机分为治疗1组和治疗2组两组，每组38例，治疗2组单纯给常规西药治疗，治疗1组在常规西药治疗的基础上加用解痉通络活血中药治疗2个月，于治疗前后对两组患者的超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-PX).丙二醛(MDA)的含量进行检测，并与30例健康体检者比较。结
2、果治疗1组治疗前血清SOD、CAT和GSH-PX水平低于对照组(P<0.01),治疗后差异无显著性(P>0.05),治疗前血清MDA水平高于对照组(P<0.01),治疗后差异无显著性(P>0.05);治疗2组治疗前血清SOD、CAT和GSH-PX水平均低于对照组(P<0.01),治疗后血清SOD、CAT和GSH-PX水平虽有提高，但差异无显著性(P>0.05),且仍低于对照组(P<0.01),治疗前血清MDA水平高于对照组(P<O.01),治疗后血
3、清MDA水平虽有下降(P<O.05)，但仍高于对照组(P<0.01)o结论解痉通络活血药物对高血压病患者的氧化应激功能紊乱的改善作用，较单纯常规西药治疗效果好。【关键词】高血压;氧化性应激;医学，中国传统Abstract:ObjectiveToinvestigatetheefficacyofemmenagogueandantispasmodiconcorrectionfunctionaldisordersofoxidativestressinpatientswithhypertens
4、ion.Methods76patientswithhypertensionwererandomlydividedintotreatinggroup1andgroup2,38casesineachgroup・Group2wastreatedwithconventionaltherapy,whi1egroup1weremainlytreatedwithemmenagogueandantispasmodic(Chinesetraditionaldrugs)plusconventionaltherapy
5、.Thesuperoxidedismutase(SOD),catalase(CAT),glutathioneperoxidase(GSH-PX)andmalondialdehyde(MDA)ofeachgroupweredetectedbeforeandafterthetreatment,andwerecomparedwiththoseof30healthycontrols・ResultsComparedgroup1tocontrolgroupbeforetreatment,thelevelso
6、fSOD,CAT,GSH-PXingroup1weresignificantlylower(P&It;0.01),whiletherewasnostatist!calsignificanceaftertreatment(P>0.05).ThelevelofMDAingroup1washigherthanthatincontrolgroupbeforetreatment,therewassignificantdifference(P&It;0.01);whiletherewasnostati
7、sticalsignificantdiffereneeaftertreatment(P>0.05)・Comparedgroup2tocontrolgroupbeforetreatment,thelevelsofSOD,CAT,GSH-PXingroup2weresignificantly1ower(P&It;0.01);andthe1evelswerestillsignificantlylowerthanthoseofcontrolgroupaftertreatment(P&It;0.01
8、),thoughthelevelsweresiightlyhigherthanthemselvesafterthetreatment,nostatisticalsignificantdifference(P>0.05)・ThelevelofMDAingroup2washigherthanthatofcontrolgroupbeforetreatment(P&It;0・01),andaftertreatmentthe1evelwasstillhigherthanthatofcontrolgr
