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1、上海交通大学学报(医学版)Vo.l27No.6Jun.2007JournalofShanghaiJiaotongUniversity(MedicalScience)#677#文章编号:0258-5898(2007)06-0677-04#基础研究#不同复用处理对聚砜血液透析器膜功能的影响12邵嘉慧,AndrewZydney(1.上海交通大学环境科学与工程学院,上海200240;2.美国宾夕法尼亚州立大学柏克校园化学工程系,PA16802)摘要:目的定量比较次氯酸盐和过氧乙酸复用处理法对FreseniusF80B聚砜血液透析器膜清除率和表面电性的影响。方法应用
2、尿素、维生素B12和多分散葡聚糖作为特征溶质,在体外模拟的透析装置上进行清除率实验,分别测定新F80B、体外透析血浆3h后以及次氯酸盐和过氧乙酸复用处理后透析器上的清除率、超滤系数和F电位。结果次氯酸盐可有效去除膜上蛋白质沉积,恢复清除率;其与透析器膜材料反应,使膜表面负电荷增加;随着接触时间的加长,可改变透析器膜的传质特性,使溶质清除率增加。过氧乙酸复用处理后,膜孔内或表面残留的蛋白质使大分子葡聚糖清除率有极大降低。结论次氯酸盐与过氧乙酸两种复用处理,对F80B聚砜血液透析器清除率和表面电性可产生不同的作用。关键词:聚砜血液透析器;复用处理;清除率;F电
3、位;超滤系数中图分类号:R695.5文献标志码:AEffectsofreprocessingtechniquesonfunctionofpolysulfonehemodialysismembranes12SHAOJia-hui,AndrewZydney12(DepartmentofEnvironmentalScienceandEngineering,ShanghaiJiaotongUniversity,Shanghai200240,China;DepartmentofChemicalEngineering,PennsylvaniaStateUniversi
4、ty,UniversityPark,PA16802,USA)Abstract:ObjectiveToquantitativelycomparetheeffectsofbleachandperaceticacidreprocessingontheclearanceandsurfacechargecharacteristicsofFreseniusF80Bpolysulfonedialyzers.MethodsClearanceexperimentswereperformedusingurea,vitaminB12,andpolydispersedextran
5、sinaninvitrodialysiscircuit.Clearance,ultrafiltrationcoefficientandzetapotentialwereobtainedonanewF80Bdialyzer,afterexposuretoplasmaina3hinvitrodialysissession,andaftercleaningwithbleachandperaceticacid.ResultsBleachwasabletoremovetheproteindeposit,restoringtheclearancecharacteris
6、tics,buttherewasasignificantincreaseinthenetnegativechargeofthemembraneduetochemicalreactionwiththebleach.Inaddition,longertimeexposuretobleachalteredthemembranetransportcharacteristics,increasingthesoluteclearance.Dialyzerscleanedwithperaceticacidhadsignificantlylowerclear-anceof
7、thelargerdextransduetothepresenceofresidualproteinonorwithinthemembrane.ConclusionCleaningwithbleachandperaceticacidmayhavedramaticallydifferenteffectsontheclearanceandsurfacechargecharacteristicsofF80Bpolysulfonedialyzers.Keywords:polysulfonehemodialyzers;reprocessing;clearance;z
8、etapotentia;lultrafiltrationcoeff
