龙脑清洁液促进烫伤大鼠创面愈合的病理学观察.pdf

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1、首都公共卫生2013年10月第7卷第5期CapitalJournalofPublicHealth，Oct．2013Vo1．7No．5中图分类号：R644文献标识码：A文章编号：1673—7830(2013)O5—0198—05·论著·龙脑清洁液促进烫伤大鼠创面愈合的病理学观察付辉高卫丽方静付怀秀毛建平【摘要】目的对龙脑清洁液治疗sD大鼠皮肤烫伤创面进行形态学和组织学观察，并探讨其机理。方法雄性sD大鼠，每只背部制作3个深Ⅱ度烫伤创面，直径1cm，分别为空白对照点、阳性药物百克瑞消毒喷剂治疗点和龙脑清洁液治疗点，观察3种处理后大鼠烫伤创面的形态学组织学

2、改变，并初步探讨机制。结果阳性药物百克瑞消毒喷剂治疗点比空白对照点结痂早，创面面积缩小快，脱痂早，光镜观察病理组织切片，阳性药物治疗点较空白对照点各组织损伤较小、再生较好；龙脑清洁液治疗点的结痂时间，创面缩小及脱痂早于阳性药物点，病理学观察皮肤的损伤及再生较阳性药物治疗点好。结论龙脑清洁液能促进大鼠烫伤创面的愈合。【关键词】龙脑清洁液；烫伤；愈合；大鼠PathologyobservationofnaturalborneolcleaningsolutioninpromotingwoundhealingofscaldratsFUHui，GAOWei-li

3、，FANGJing，FUHuai—xiu，MAOJian—ping(InstituteofRadiationMedicine，AcademyofMilitaryMedicalScience，Beng100850，China)【Abstract】ObjectiveToobservetheeffectofNaturalBorneolCleaningSolutionontreatmentofburnedskininSDrats，andtoexplorethemechanism．MethodsThreewoundsiteswerechosenonthebac

4、kofeachmalerat．Afterhairremovingandanesthesia，a100gramsironbarwhichhadbeenkeptinboilingwaterheatingforlOminswasputonthechosensitefor6secondstomaketwodegreeburnwounds，diameterofthewoundis1centimeter．Thewoundsitesweresetasblankcontrolpoint，positivedrugBaiKeRuitreatmentandNaturalB

5、orneolCleaningSolutiontreatment．Observethemorphologicalandhistologicalchangeofthreescaldedsitesinratsandpreliminarystudyofmechanismwasconducted．ResultsComparedwiththeblankcontrolpointthepositivedrugBaiKeRuispraydisinfectanttreatmentleadtoearlierscabformation，smallerwoundareaand

6、earlierscabdetachment．Histologicalobservationshowedthattissueinjuryareainpositivedrugsitesissmallerandregenerationisbetterthanthoseinblankcontrolpoint；Moreover，thewoundareareduction，scabformationanddetachmenttimeofthesitesundergoingNaturalBorneolCleaningSolutiontreatmentareearl

7、ierthanthosesitesundergoingpositivedrugtreatment．PathologicalobservationshowedmilderinjuryandbetterregenerationofskintissueinsitesofNaturalBorneolCleaningSolutiontreatmentcomparingwiththoseinsitesofpositivedrugtreatment．ConclusionTheNaturalBorneolCleaningSolutioncouldimprovethe

8、healingandrepairofskinscald．【Keywords】NaturalBorneolCl