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《地特胰岛素联合门冬胰岛素治疗2型糖尿病临床疗效评估.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、海南医学2014年6月第25卷第12期FlaimmnMedJ.Jan.2014,Vo1.25,No.12doi:10.39690.issn.1003—6350.2014.12.0673地特胰岛素联合门冬胰岛素治疗2型糖尿病临床疗效评估蒙光义,庞家莲,王冬晓,彭评志,梁慧,张萍(1.玉林市第一人民医院药学部,广西玉林537000;2.玉林市妇幼保健院药剂科,广西玉林537000;3.玉林市第一人民医院内分泌科,广西玉林537000)【摘要】目的观察地特胰岛素治疗2型糖尿病对胰岛素和C肽、果糖胺和糖化血红蛋白水平变化的影响
2、,评估其临床疗效。方法将160例2型糖尿病患者随机分为两组,分别应用地特胰岛素联合门冬胰岛素(地特胰岛素组,82例)和甘精胰岛素联合门冬胰岛素(甘精胰岛素组,78例)治疗12周,观察两组治疗2型糖尿病前后的空腹胰岛素、餐后2h胰岛素、C肽、果糖胺(FMN)和糖化血红蛋f~frroA。c】水平的变化情况。结果治疗后两组患者的空腹胰岛素和CJlk~平均明显高于治疗前的空腹水平(P3、餐后2hC肽与治疗前比较差异无统计学意义(P>0.05)。两组患者治疗后的FMN和HbA。。与治疗前比较均明显低于治疗前水平(P<0.01),但组间比较差异无统计学意义(P>0.05)。结论地特胰岛素能够明显地改善和促进胰岛细胞功能的恢复,能够有效地降低血糖,对胰岛细胞功能的影响强于甘精胰岛素,可以作为临床治疗2型糖尿病的理想方案。【关键词】地特胰岛素;甘精胰岛素;f-j冬胰岛素;2型糖尿病;c肽;果糖胺;糖化血红蛋白【中图分类号】R587.1【文献标识码】A【文章编号】1003--6350(2014)12一l73o-4、-04Clinicalemcacyevaluationofinsulindetermircombinedwithinsulinaspartintype2diabetes.MENGCuang-yiPANGJia-lian1WANGDong-xiao2pPENGPing-zhil。HANGHui3。ZHANGPing3.1.DepartmentofPharmacy,theFirstPeople"sHospital,Yulin537000,Guangxi,CHINA;2.DepartmentofP^口rtheMaternal5、andChildHealth-CareHospital,Yulin537000,Guangxi,CHINA;iDepartmentofEndocrinology,theFirstPeople"sHospital,Yulin537000,Guangxi,CHINA【Abstract】ObjectiveToobservetheinfluenceofinsulindetemircombinedwithinsulinaspartonthelevelsofinsulin,C-peptid,fruetosamineandglyca6、tedhemoglobinincuringtype2diabetespatients,andevaluatetheclinicaleficacy.Methods160casesofthetype2diabeticpatientswererandomizeddividedintoinsulindetermirgroup.whichweregiveninsulindetermircombinedthinsulinaspart(n=82),andinsulinglarginegroup,whichweregivennsuli7、nglarginecombinedwithinsulinaspart(,78).ARer12weeksoftreatment,thelevelsofinsulin,C-peptide,fruc-tosamine(FMN)andglycatedhemoglobin(HbA~)wereobservedandcomparedbetweengroupsatthebaselineandattheendoftheexperiment.ResultsARer12weeksoftreatment,thelevelsofinsulina8、ndC—peptideincreasedsignifl—cantlyfrombaselineinthetwogroupsrP<0.01).TheleveloftwohourpostIrandialinsulinincreasedsignificantlyfrombaselineininsulindetermirgroup(P<0.
3、餐后2hC肽与治疗前比较差异无统计学意义(P>0.05)。两组患者治疗后的FMN和HbA。。与治疗前比较均明显低于治疗前水平(P<0.01),但组间比较差异无统计学意义(P>0.05)。结论地特胰岛素能够明显地改善和促进胰岛细胞功能的恢复,能够有效地降低血糖,对胰岛细胞功能的影响强于甘精胰岛素,可以作为临床治疗2型糖尿病的理想方案。【关键词】地特胰岛素;甘精胰岛素;f-j冬胰岛素;2型糖尿病;c肽;果糖胺;糖化血红蛋白【中图分类号】R587.1【文献标识码】A【文章编号】1003--6350(2014)12一l73o-
4、-04Clinicalemcacyevaluationofinsulindetermircombinedwithinsulinaspartintype2diabetes.MENGCuang-yiPANGJia-lian1WANGDong-xiao2pPENGPing-zhil。HANGHui3。ZHANGPing3.1.DepartmentofPharmacy,theFirstPeople"sHospital,Yulin537000,Guangxi,CHINA;2.DepartmentofP^口rtheMaternal
5、andChildHealth-CareHospital,Yulin537000,Guangxi,CHINA;iDepartmentofEndocrinology,theFirstPeople"sHospital,Yulin537000,Guangxi,CHINA【Abstract】ObjectiveToobservetheinfluenceofinsulindetemircombinedwithinsulinaspartonthelevelsofinsulin,C-peptid,fruetosamineandglyca
6、tedhemoglobinincuringtype2diabetespatients,andevaluatetheclinicaleficacy.Methods160casesofthetype2diabeticpatientswererandomizeddividedintoinsulindetermirgroup.whichweregiveninsulindetermircombinedthinsulinaspart(n=82),andinsulinglarginegroup,whichweregivennsuli
7、nglarginecombinedwithinsulinaspart(,78).ARer12weeksoftreatment,thelevelsofinsulin,C-peptide,fruc-tosamine(FMN)andglycatedhemoglobin(HbA~)wereobservedandcomparedbetweengroupsatthebaselineandattheendoftheexperiment.ResultsARer12weeksoftreatment,thelevelsofinsulina
8、ndC—peptideincreasedsignifl—cantlyfrombaselineinthetwogroupsrP<0.01).TheleveloftwohourpostIrandialinsulinincreasedsignificantlyfrombaselineininsulindetermirgroup(P<0.
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