基因毒性杂质之结构警示(欧洲).pdf

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1、DevelopmentofstructuralalertsfortheinvivomicronucleusassayinrodentsaaaRomualdoBenigni,CeciliaBossa,OlgaTcheremenskaiabandAndrewWorthaIstitutoSuperiorediSanita’,EnvironmentandHealthDepartment,Rome,ItalybInstituteforHealth&ConsumerProtection,EuropeanCommission-JointResearchCentre,Ispra,ItalyE

2、UR23844EN-2009ThemissionoftheIHCPistoprovidescientificsupporttothedevelopmentandimplementationofEUpoliciesrelatedtohealthandconsumerprotection.TheIHCPcarriesoutresearchtoimprovetheunderstandingofpotentialhealthrisksposedbychemical,physicalandbiologicalagentsfromvarioussourcestowhichconsumer

3、sareexposed.EuropeanCommissionJointResearchCentreInstituteforHealthandConsumerProtectionContactinformationAddress:TP582E-mail:andrew.worth@ec.europa.euTel.:+390332789566Fax:+390332786717http://http://ecb.jrc.ec.europa.eu/qsar/http://ec.europa.eu/dgs/jrc/LegalNoticeNeithertheEuropeanCommissi

4、onnoranypersonactingonbehalfoftheCommissionisresponsiblefortheusewhichmightbemadeofthispublication.AgreatdealofadditionalinformationontheEuropeanUnionisavailableontheInternet.ItcanbeaccessedthroughtheEuropaserverhttp://europa.eu/JRC52274EUR23844ENISSN1018-5593Luxembourg:OfficeforOfficialPub

5、licationsoftheEuropeanCommunities©EuropeanCommunities,2009ReproductionisauthorisedprovidedthesourceisacknowledgedPrintedinItalyABSTRACTInvivomutagenicityandcarcinogenicitystudiesareposingahighdemandfortest-relatedresources.Amongthesestudies,themicronucleustestinrodentsisthemostwidelyused,as

6、followuptopositiveinvitromutagenicityresults.Arecentsurveyofthe(Q)SARmodelsformutagenicityandcarcinogenicityhasindicatedthatno(Q)SARmodelsforinvivomicronucleusareavailableinthepublicdomain.Therefore,thedevelopmentandextensiveuseofestimationtechniquessuchas(Q)SARs,read-acrossandgroupingofche

7、micals,promisestohaveahugeanimalsavingpotentialforthisendpoint.Inthisreport,wedescribetheidentificationofstructuralalertsfortheinvivomicronucleusassay,andprovidethelistofunderlyingchemicalstructures.Thesestructuralalertsprovideacoarse-grainfilterforthepr