sup99msup Tc-NOET心肌灌注显像的初步临床应用.doc

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1、^99mTc-NOET心肌灌注显像的初步临床应用临床心血管病杂志2000年第7期第16卷影像学作者:蒋宁一卢献平梁九根刘生邵季书刘幸光陈少雄王景峰陈锡龙肖辉盛方平单位：蒋宁一卢献平梁九根刘生邵季书刘幸光陈少雄(中山医科大学孙逸仙纪念医院核医学科广州，510120)；王景峰陈锡龙肖辉盛(中山医科大学孙逸仙纪念医院心内科)；方平(江苏省原子医学研究所卫生部重点实验室)关键词：放射性核素显像；心肌缺血；冠状动脉疾病摘耍目的：观察99mTc-NOET心肌灌注显像剂在心肌组织中的再分布特性及其对心脏缺血性疾病的诊断价值。方法：对52例冠心病心绞痛患者进行

2、了运动负荷试验，静脉注射99mTc-NOET后30min行心肌断层显像,3〜4h行再分布显像。常规心肌断层显像采集和图像重建后观察放射性分布现象并评价英诊断价值。结果：52例中40例运动心肌灌注断层显像1个以上节段出现放射性稀疏■缺损区,38例岀现明显放射性再分布。其中5例同期做冠状动脉造影对照，4例与99mTc-NOET结论吻合。结论：99mTc-NOET是-•种良好的新型心肌灌注显像示踪剂,它具有明显心肌再分布特性,对心肌缺血性病变的临床评价有价值。Preliminaryclinicalstudyofmyocardialimagingagent99mTc-NO

3、ETJIANGNing-yiLUXian-pingLIANGJiu-genLIUShengSHAOJi-shuLIULing-guang(DepartmentofNuclearMedicine，MemorialHospital,Sen-YatsunUniversityofMedicalSciences,Guangzhou510120)CHENShao-xiongWANGJin-fengCHENXi-longXIAOHui-sheng(DepartmentofCardiogy,MemorialHospitahSen-YatsunUniversityofMedical

4、Sciences;)FANGPing(InstituteofNulearMedicine)AbstractObjective:Tostudythemyocardialredistributionandclinicalevaluationofmyocardialimagingagent99mTc-NOET(bis(N-ethoxy,N-ethyldithiocarbamato)nitrido99mTc)・Method:52patientswithcoronaryarterydiseaseunderwentexercisemyocardialperfusionscin

5、tigraphyandnuclidemyocardialredistributionimaging,theformerwasundergoneat30minandthelatterwasperformedat3to4hafterinjectionof99mTc-NOET.Result:40of52casesshowedtherelativehypoactivity(theactivitywasreductedordefected)inoneoronemoresegmentsofmyocardiumduringexercisemyocardialperfusions

6、cintigraphywith99mTc-NOET.Oftheseabnormidsegments,while,38of40casesshowedimprovedactivityontheimagesobtmned3to4hafter99mTc-NOETinjection.Allofimagingresultscoincidedwiththeclinicaldiagnosis.4of5casesimaging99mTc-NOETwereparalledwithcoronaryangiography.Conclusion:The99mTc-NOEThassignif

7、icantcharacterofmyocardialredistributionasamyocardialperfusionimagingagent.Itcanbeusedtoobserveandevaluatethemyocardialischemia・KeywordsRadionuclideimagingMyocardialischemiaCoronarydisease心肌灌注显像是评估心肌血流分布情况的常用方法。日前，临床常用的心肌显像剂主要有201T1、99mTc-MIBI等，但都不同程度地存在一些不足之处：201T1需耍加速器，生产价格较窩而且能量偏低成

8、像不理想；