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时间:2020-06-03
《缺血性卒中后非流利型失语患者静息态功能磁共振比率低波振幅的研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、实用医学杂志2014年第30卷第7期·专题报道·缺血性卒中后非流利型失语患者静息态功能磁共振比率低波振幅的研究许光马晓芬江桂华李淑美田军章詹文峰方金邱迎伟摘要目的:对缺血性卒中后非流利型失语症患者的静息态功能磁共振原始数据进行比率低频振幅的处理分析,探讨其脑功能损伤及代偿的病理机制。方法:对17例失语患者(患者组)及l9例年龄、性别、受教育程度均匹配的健康对照者(正常组)进行静息状态下的功能磁共振成像扫描,扫描序列为回波平面成像序列。应用DPARSF软件进行数据处理,并进行对比分析。结果:同正常组比较,患者组右侧颞上回、顶下小叶、中央后回
2、及额叶皮层的fALFF值增高;右侧丘脑及双侧的小脑半球的fALFF值明显降低。结论:静息状态下,缺血性卒中后非流利型失语的患者在某些脑区存在异常激活。反映其脑功能失调的病理变化.为临床从大脑神经活动层面进一步了解失语症损伤及其代偿过程提供了客观依据。关键词卒中;缺血性卒中后非流利型失语;功能磁共振成像;比率低频振幅Resting-statefMRIfALFFanalysisinpatientswithnon-fluentaphasiaafterischemicstrokeXUGuang,MAXiaofen,JIANGGui—hua,Shu
3、—mei,TIANJun—zhang,ZHANWen-feng,FANGn,QIUYing-wei.GuangdongSecondProvincialPeopleSHospital,SouthernMedicalUniversity,Guangzhou510317,ChinaCorrespongdingauthor:TIANJun—ZhangE—mail:tianjz2010@163.com【Abstract】ObjectiveTounde~tandtheimpairmentandcompensationmechanismofbrainf
4、unctioninpa—tientswithnon—fluentaphasiaafterischemicstroke.Thefractionalamplitudeoflow~equencyfluctuation(fALFF)methodwasusedtoanalyzethefunctionalmagneticresonanceimaging(fMRI)dataintherestingstatebetweentheaphasiapatientsandthenormalcontrols.MethodsThescansoftherestings
5、tateoffMR1wereperformedin17aphasiapatientsand19age一,education一,andsex—matchedhealthycontrolsubjects.Thescansequencewassingle—shotechoplanarimage,DPARSFsoftwarewasusedtoanalyzefALFFdataoftheaphasiapatientsandthehealthycontrols.ResultsComparedtothecontrolgroup,thevalueinrig
6、htsuperiortemporalgums,inferiorparietallob—ule,frontallobecodex,andpostcentralgumsweresignificantlyincreasedintheaphasiagroup.ThefALFFinbilat—eralcerebellumandrightthalamuswerealsodecreasedintheaphasiagroup.ConclusionsThefALFFvaluesinsomebrainregionintheaphasiagroupwereab
7、normalintherestingstate,indicatingafewpathologicalchangeofbrainfunctioninpatientswithnon—fluentaphasiaafterischemicstroke.【Keywords】Stroke;Non—fluentaphasiaafterischemicstroke;Functionalmagneticresonanceimaging;FractionalamplitudeoflOWfrequencyfluctuation卒中后失语(poststrokea
8、phasia,PSA)是由卒中特点,同时还伴随严重的神经系统症状如偏瘫,严导致的获得性语言障碍,急性缺血性脑卒中后,重影响了患者的Et常生活质量。目前,卒中后损PSA的发病率约20%~40%,
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