高、低频重复经颅磁刺激联合舍曲林治疗帕金森病患者伴抑郁的疗效研究.pdf

《高、低频重复经颅磁刺激联合舍曲林治疗帕金森病患者伴抑郁的疗效研究.pdf》由会员上传分享，免费在线阅读，更多相关内容在应用文档-天天文库。

1、·2164·ModDiagnTreat现代诊断与治疗2013Jul24(10)高、低频重复经颅磁刺激联合舍曲林治疗帕金森病患者伴抑郁的疗效研究吴卓华，岑慧红，崔立谦-，林杰，许起峰t，吴宜娟，谭红愉-，李少明，邵明(1．广州医学院第一附属医院，广东广州510120；2．广州医学院卫生职业技术学院，广东广州510120)EficacyStudiesofHighandLowFrequencyRepetitiveTranscranialMagneticStimulationJointSertralineintheTreatmentofParkinson’SDi

2、seasePatientswithDepressionWIJZhuo—hua1,CENHui—hong2,CUILi—qian1,LINJiel,XUQi—feng1,WIJYi-juan1,TanHong—yu．LIShao—ming1,SHAOMing．FirstAffiliatedHospitalofGuangzhouMedicalCollege，Guangzhou510120,China,'2．GuangzhouMedicalHealthVocational&TechnicalCollege，Guangzhou510120,China)Abstr

3、act：ObjectiveToinvestigateapplicationeffectandsafetyonlowandhighfrequencyrepetitivetranseranialmagneticstimulationjointsertralineinthetreatmentofParkinson’Sdiseaseinpatientsdepression．Methods70patientswithParkinson’Sdiseasewhoweredividedinto3groups．Patientsinlow—frequencystimulat

4、iongroup(n=22)weregivendorsolateralprefrontalcortexrTMS，stimulationfrequency1Hz．Patientsinhigh—frequencystimulationgroupweregivenfightDLPFCrTMS．Patientsinfakestimulationgroup(n=23)weregivenpseudo—stimulationtherapyofleftandfightsidecorrespondingparts．Afterthreeweeks，thescoresofha

5、miltondepressionscalescoresandUPDRSwerescoredinthreegroups．Thechangesofscalescorefrombaselinevalueswereobservedandcomparedbetweengroups，eachgroupwasrecordedadversereactionsduringthetreatment．ResultsTherewasnosignifi—cantdiferencebetweenHAMDscoreandUPDRSscoreinthethreegroupsbefore

6、treatment．Afterin—tervention，fakestimulationgrouphadnosignificantchanges；ThescoresofHAMDandUPDRSwasob—viouslyimproved(P<0．05)inlow—frequencystimulationgroupandhigh—frequencystimulationgroup．HAMDscoreofhigh—frequencystimulationgroupwaslowerthanthatinlow—frequencystimulationgroup．D

7、ifferencewasstatisticallysignificant(P<0．05)．ConclusionHighfrequencyandlowfrequencyprefrontalsimulatedrepetitivelyallhavedualroleofimprovingmotorsymptomsofParkinson’Spatientsanddepressivesymptoms．ClinicalefficacyiSsafe．reliable．Andithaslessadversereaction．Keywords：Frequencyrepeti

8、tivetranscranialmagneticstimulation；Sert