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时间:2020-06-06
《慢性心力衰竭中医辨证分型与血清胱抑素C及同型半胱氨酸的相关性研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、·386·中国中西医结合急救杂志2014年9月第21卷第5期ChinJTCMWMCritCare,September2014,Vo1.21,No.5·论著·慢性心力衰竭中医辨证分型与血清胱抑素C及同型半胱氨酸的相关性研究蔡宏文,李洋威,吕淑敏,戴金,黄兆铨,毛威(浙江中医药大学附属第一医院心内科,浙江杭州310006)【摘要】目的探讨慢性心力衰竭(CHF)患者中医辨证分型与血清胱抑素c(Cys—C)和同型半胱氨酸(Hcy)的相关性。方法选择浙江中医药大学附属第一医院心内科收治的115例CHF患者作为CHF组,以同期本院30例健康体检者作为健康对照组,再将CHF患者按中医辨证分型
2、标准分为气阴两虚证30例,气虚血瘀证3O例,心肾阳虚证30例和阳虚水泛证25例。检测各组血清Cys—C和Hcy水平,采用Spearman等级相关分析评价不同中医证型与血清Cys—C和Hcy的相关性。结果CHF组Cys—C和Hcy水平显著高于健康对照组[Cys—C(me/L):1.24±0.34比0.77±0.22,Hcy(pmol/L):18.66±4.57比11.65±3.21,均P<0.05]。与健康对照组比较,Cys—C和Hcy水平按气阴两虚证、气虚血瘀证、心肾阳虚证和阳虚水泛证的顺序呈逐渐增高趋势[Cys—C(me-/L):1.02±0.27、1.09±0.31、1.3
3、2±0.22、1.59±0.25;Hcy(~xmol/L):14.94±2.20、17.66±3.04、l9.79±3.48、22.96±5.31],且以阳虚水泛证的升高程度最明显(P<0.05)。相关分析显示,不同中医证型与血清Cys—C和Hcy水平呈显著正相关(r.:O.73,r2=O.79,均P<0.05)。结论CHF患者血清Cys—C和Hey水平的变化与其辨证分型规律的演变相一致,两者可作为CHF中医辨证分型的客观指标。【关键词】慢性心力衰竭;胱抑素C;同型半胱氨酸;辨证分型AstudyofrelationshipsbetweentraditionalChineseme
4、dicinesyndromedifierentiationandserumcystatinCandhomocysteineinpatientswithchronicheartfailureCaHongwen,LYangwei,LyuShumin,DaJin,HuangZhaoquan,Mao眈.DepartmentofCardiology,theFirstAffiliatedHospital,qiangChineseMedicalUniversity.Hnngzhou31ooo6,Zheiiang.ChinaCorrespondingauthor:Ca11ongwen,Emai
5、l:chw~u2002@163.con[Abstract]0biecfiveToinvestigatetherelationshipsbetweentraditionalChinesemedicine(TCM)syndromedifferentiationandserumcystatinC(Cys—C)andhomocysteine(Hcy)inpatientswithchronicheartfailure(CHF).Methods115caseswithCHFadmittedintotheDepartmentofCardiologyoftheFirstAmliatedHosp
6、italofZhejiangChineseMedicalUniversitywereselectedintheCHFgroup.and30caseswhohadtakenheahhexaminationinthesameperiodwerechoseninthehealthycontrolgroup.AccordingtotheTCMsyndromedifferentiation.theCHFcasesweresubdividedintofonrgroupswithdifferenttypesofsyndrome:30casesofdeficiencyofboth9iandYi
7、nsyndrome,30casesof9ideficiencysyndromeandbloodstagnationsyndrome,30casesofheartandkidneyYangdeficiencysyndromeand25casesoffloodingduetoYangdeficiencysyndrome.TheserumlevelsofCys—CandHcyindifferentgroupsweretested,andtherelationshipsbetweenTCMsyndr
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