国外最新医学.pdf

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1、世界最新医学信息文摘2013年第13卷第15期国外最新医学摘要●EarlyonsetversuslateonsetinAlzheimer’sdisease：Whatisthereliablecut—off7．Author(s)GianfrancoSpalleRa，VincenzoDeLuca，AlessandroPadovani，LucaRozzini，RobertaPerri，AmaliaBruni，VincenzoCanonico，AlbertoTrequattrini，GiuseppeBellelli，CariaPeRenati，Florian

2、aPazzelli，CarloCaltagirone，MariaDonata0rfeiABSTRACTObective：Astheliteratureonconventionalcriteriafordiscriminatingearly．onset(E0)fromlate．onset(L01Alzheimer’sdisease(AD)issparseandcontroversial，theaimofthisstudywastoestablishapreciseageatonset(AAO)criterion，byusingaspecificstat

3、isticalprocedure．andtodescribetheclinicalcharacteristiesofthetwosub．groups．Methods：AdmixtureanalysiswasperformedtoestablishtheAAOcut—-offinamulti．．centerstudyincluding2000ADpatientsconsecutivelyrecruitedineightItalianMemoryClinics．Noneofthepatientsweretakingacet3lcholinesterase

4、inhibitors。antipsychoticoranti．depressantdrugs．Atthefirstdiagnosticvisit，theywereadministeredtheMiniMentalStateExamination，theBasicandInstrumentalActivitiesofDailyLivingandtheNeuropsychiatricInventorytoassessclinicalphenomenology．Results：Usingaspecificstatisticalprocedure，weest

5、ablishedthatAA0thatdiscriminatedEO．fromLO．ADwas66．Comparedwi也theLO．ADgroup．theEO．ADgroupshowedlongerdurationofillnessandahighereducationallevelaswellaslessseverefunctionalimpairmentanddelusions．Conclusions：Differencesinsociodemographicandclinicalcharacteristics，suchasdurationof

6、illness，educationanddelusionseverity,suggestedtheinvolvementofdiferentpathogenicprocesses．Additionalstudiesareneededtofurtherinvestigatethemechanismsunderlyingthedisorderinthetwosub．groupsOfADpatients．KEYW0RDSAlzheimer’sDisease；Onset；NeuropsychiatrieSymptoms；AdmixtureAnalysis；P

7、athogenesis；CognitiveReserveTheevaluationofironcontentinAlzheimer’sdiseasebymagneticresonanceimaging：Phaseand1t2methodsAuthor(s)BijingZhou，SiyaoLi。Hu~iinHe，XiaoyuanFengABSTRACTBackground：Magneticresonanceimaging(MRI)isthebestimagingexaminationtoevaluateabnormalirondepositionint

8、hebrain．A1thoughphaseofsusceptibilityweightedimaging(S