磁共振弥散加权成像对索拉菲尼治疗肝细胞癌的疗效评估.pdf

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1、Zhaoeta1．／JZhejiangUniv-SciB(Biomed＆Biotechno1)201415(8)：713—719713JournalofZhejiangUniversity—SCIENCEB(Biomedicine&Biotechnoogy)ISSN1673—1581(Print)；ISSN1862—1783(Online)www．zju．edu．cn~zus；www．springerlinkcomE—mail：jzus@zju．edu．onEarlychangesinapparentdiffusioncoeficientasan

2、indicatorofresponsetosorafenibinhepatocellularcarcinomaYi—leiZHAO，Qing—quGU0，Gen—renYANG，Qi—dongWANG(JDepartmentofRadiology,theFirstAffiliatedHospitalSchoolofMedicine,ZhejiangUniversity,Hangzhou310003，China)(DepartmentofSurgery,theSecondAfiliatedHospital,SchoolofMedicine,Zhej

3、iangUniversity,Hangzhou310009,China)E—mail：quguoqing1973@163．comReceivedJan．8，2014；RevisionacceptedJune9，2014；CrosscheckedJuly18，2014Abstract：Objective：Therelationshipbetweenapparentdiflusioncoefficient(ADC)andchemotherapyhasbeenestablished．However．whetherADCcouldbeconsidered

4、asameasureformonitoringresponsetosorafenibinhepatocellularcarcinoma(HCC)hasnotbeendemonstrated．ThisstudywastoinvestigatetheADCchangesofad．vancedHCCundersorafenibtreatment．Methods：AthymicmicewithHepG2xenograftswereallocatedtotwogroups：controIandsorafenib(40mg／kg，bid)．T2anddifl

5、usionimageswereacquiredateachtimepoint(0，1O。14，and18dpost-therapy)．TumorvolumeandchangesinADCwerecalculated．Results：TumorvolumesonDays10。14，and18aftertreatmentshowedsignificantdecreasesinthesorafenib-treatedgroupcomparedwiththecontro1．PretreatmentADCvalueswerenotsignificantly

6、differentbetweenthecontrolandtreatedgroups．AslowincreaseinADCintheperipheralzoneoftumorsappearedinthetreatedgroup．whichwassignificantlyhighercomparedwiththecontrolgrouponDays10，14，and18．InthecentralpartoftumorsonDay10aftertreatment，anincreaseinADCappearedjnthetreatedandcontro

7、Igroups．theADCofthecontrolgroupbeingsignificantlyIowercomparedwiththetreatedtumorsFromDay10toDay14．theADCmapshowedaprogressivedecreaseinthecentraIregionoftumorsinthetreatedandcontrolgroups．However．thischangeismoresignificantinthetreatedgroups．Conclusions：EarlychangesinmeanADC

8、correlatedwithsorafenibtreatmentinHCC．whicharepromisingindicatorsfor