血栓通冻干粉针剂治疗肾病综合征高凝及高脂状态的临床效果分析.doc

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1、血栓通冻干粉针剂治疗肾病综合征高凝及高脂状态的临床效果分析作者：陶建勋，米绪华左△，樊均明单位:攀钢集团成都医院内科,四川成都610066；四川大学华西医院肾内科,四川成都610041【摘要】目的探讨血栓通冻干粉针剂治疗肾病综合征高凝及高脂状态的临床效果。方法30例肾病综合征患者随机分为治疗组(16例)和对照组(14例)，在常规治疗的基础上，治疗组用血栓通冻干粉针剂150mg加入5%葡萄糖注射液100ml静脉滴注，每日1次抗凝、降脂治疗；对照组用低分子肝素钠抗凝、晋伐他汀钠降脂治疗，连用4周，两组疗程相同。治疗前后检测凝血指标、血脂状况及其

2、他生化指标。结果疗程结束后两组患者凝血指标、血脂状况与治疗前相比均有统计学意义，但两组间比较无统计学意义。结论血栓通冻干粉针剂应用治疗肾病综合征高凝及高脂状态是一种安全有效的抗凝、降脂治疗措施，且价格低廉，效果确切，值得在临床推广应用。【关键词】血栓通冻干粉针剂；肾病综合征；抗凝；降血脂ClinicalEffectAnalysisofXueshuantongLyophilizedPowderforInjectiononHypercoagulationandHyperlipidemiaofthePatientswithNephroticSyn

3、dromeTaoJianxun,MiXuhua,FanJunming,ChengduHospitalofPanzhihuaSteelCooperation,Chengdu,SichuanProvince610066ABSTRACTObjectiveTodiscusstheclinicaleffectofXueshuantongLyophilizedPowdertbrInjectiononhypercoagulationandhyperlipidemiaofthepatientswithnephriticsyndrome.Methods30c

4、aseswithnephriticsyndrometreatedwithroutinetherapywererandomlydividedinto2groups:treatmentgroup(n=16)andcontrolgroup(n=14);patientsintreatmentgroupreceivedintravenousinfusionof150mgofXueshuantongLyophilizedPowderin100mlof5%glucoseforanti-coagulationandlipidreduction,oncead

5、ay;patientsincontrolgrouphadacontinuousadministrationoflowmolecularweightheparinsodiumtbranti-coagulationandpravastatinsodiumforlipidreductionfor4weeks;thecoursesofbothgroupswerethesame;beforeandaftertreatment,thecoagulationindexes,thebloodlipidlevelandotherbiochemicalinde

6、xesofallthepatientsinbothgroupswerecollected.ResultsThecomparisonofthecoagulationindexes,thebloodlipidlevelandotherbiochemicalindexesofallthepatientsbeforetreatmentandthoseaftertreatmentwasofstatisticalsignificancewhilethecomparisonbetweenthe2groupshadnostatisticalsignific

7、ance.ConclusionsXueshuantongLyophilizedPowdertbrInjectionissafeandeffectiveintreatinghypercoagulationandhyperlipidemiaofthepatientswithnephriticsyndromeKEYWORDSXueshuantongLyophilizedPowerforInjectionnephriticsyndromeanti-coagulationbloodlipidreduction肾病综合征是以大量蛋白尿、低白蛋白血症、高

8、脂血症及水肿为主要表现的常见临床综合征，患者存在不同程度的血液高凝状态，易于形成血栓，发生率可高达10%〜40%,常因此而导致急性肾衰竭、肢端坏死、肺栓塞等严重后果，为此，抗凝、