非肥胖2型糖尿病合并非酒精性脂肪性肝病危险因素及与并发症的相关性研究.pdf

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1、论著·中国现代医生2014年5月第52卷第14期非肥胖2型糖尿病合并非酒精性脂肪性肝病危险因素及与并发症的相关性研究袁春钢黄篙1．浙江省富阳市人民医院内分泌科，浙江富阳311400；2．浙江大学附属邵逸夫医院心内科．浙江杭州310000【摘要】目的研究非肥胖2型糖尿病合并非酒精性脂肪性肝病危险因素及与并发症的相关性。方法选择428例非肥胖2型糖尿病患者，分为非酒精性脂肪性肝病组(NAFLD组)193例和非NAFLD组235例，对比两组生活指标、物理指标、一般资料及慢性并发症发生率，分析2型糖尿病合并NAFLD的危险因素。结果NAFLD组外周血HbA1C、FINS、C肽、HOMA—

2、IR、TC、TG、LDL-C、ALT、AST、uA水平均显著高于非NAFLD组(P

3、性脂肪性肝病；危险因素；并发症，慢性；胰岛素抵抗【中图分类号】R575【文献标识码】A【文章编号】1673—9701(2014)14—0012—04Riskfactorsandcomplicationsofnon-obesetype2diabetesmellituswithnonalcoholicfattyliverdiseaseYUANChungang'HUANGHe1．DepartmentofEndocrinology，FuyangPeople'sHospitalinZhejiangProvince，Fuyang311400，China；2．DepartmentofCardi

4、ology，AfiliatedRunRunShawHospital，ZhejiangUniversity，Hangzhou310000，China【Abstract]ObjectiveTostudytheriskfactorsandcomplicationsofnon-obesetype2diabetesmellituswithnonaleo'holicfattyliverdisease．MethodsAtotalof428casesofnon—obesetype2diabeticpatientsweredividedintogroupsofnon-alcoholicfattyl

5、iverdisease(NAFLDgroup)of193casesandnon-NAFLDgroupof235cases，comparelivingindex，physicalindicators，generalinformationandchroniccomplicationsrateoftype2diabetesriskfactorsforNAFLDoftwogroups．ResultsNAFLDperipheralbloodHbA1C，FINS，Cpeptide，HOMA—IR，TC，TG，LDL—C，ALT，AST，UAlevelsweresignificantlyhig

6、herthannon—NAFLDgroup(P<0．05)，AST／ALTratioweresignificantlylowerinnon-NAFLDgroup(P<0．05)．NAFLDgroupBMI，waist—hipratioweresignificantlyhigherthannon—NAFLDgroup(P<0．05)．IncludedHOMA-IR，TG，LDL—C，waist—hipratioweretype2diabetesmellituswithnonalcoholicfattyliverdiseaseriskfactors(P<0．05)．NAFLDgrou

7、pdiabeticnephropathy，hypertension，atherosclerosis，coronaryheartdisease．cerebrovasculardiseaseincidenceweresignificantlyhigherthannon-NAFLDgroup(P<0．05)．Conclu-sionInsulinresistance，dyslipidemiaandfatmaldistributionandnon-obesetype2diabeticpat