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《脑心通胶囊联合低分子肝素钙对急性冠脉综合征患者血清hs-CRP、IL-6及血脂的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、·论著·中国现代医生2014年6月第52卷第17期脑心通胶囊联合低分子肝素钙对急性冠脉综合征患者血清hs-CRP、IL-6及血脂的影响杜晓马蔡建丽沈昕浙江省金华市中医医院心血管内科。浙江金华321017[摘要】目的评价脑心通胶囊联合低分子肝素钙对急性冠脉综合征患者血清hs—CRP、IL一6及血脂的影响。方法88例老年急性冠脉综合征患者,随机分为对照组和观察组,每组44例。对照组采用常规治疗;观察组在对照组常规治疗方式基础上,加用低分子肝素钙注射液及脑心通胶囊治疗。结果经过治疗,观察组患者LVEF、CO、E/A的改善情况显著优于对照组,差异有统计学意义(P<0.01或0.05
2、)。治疗后观察组心绞痛发作次数及持续时间分别为(1.9~0.5)次、(1.6~0.4)min,少于对照组的(4.5~1.3)次、(4.8~1.2)min,差异有统计学意义(P<0.01)。治疗后观察组患者CHOL、TG及LDL—C分别为(5.13~0.53)mmol/L、(2.34~0.55)mmol/L、(2.15~0.65)mmo]L,低于对照组的(6.36~0.58)mmo1]L、(3.57~0.88)mmol/L、(3.16~0.33)mmol/L,差异有统计学意义(P3、3~1.1)mg/L,低于对照组的(8.25~2.2)ng/L、(4.2~1.3)mg/L,差异有统计学意义(P<0.01或P<0.05)。结论脑心通胶囊联合低分子肝素钙治疗急性冠脉综合征疗效显著,并能改善患者血清hs—CRP和IL一6及血脂水平。【关键词】脑心通胶囊;低分子肝素钙;急性冠脉综合征;高敏C反应蛋白;白细胞介素6;血脂[中图分类号】R542.2+2【文献标识码】A【文章编号】1673—9701(2014)17—0008—04Naoxintongcapsuleincombinationwithnadroparincalcium’sefectonserumhs—C4、Rjf'.IL一6andlipidsofpatients、thacutecoronarysyndromeDUXiaomaCAIJiontiSHENXinCardiovascularDepartment,JinhuaCityHospitalofTraditionalChineseMedicineinZhejiangProvince,Jinhua321017,China[Abstract]ObjectiveTostudytheeffectofnaoxintongcapsulecombinationnadroparincalciumonserumhs-CRP,IL-6andlip5、idsofpatientswithacutecoronarysyndrome.MethodsAtotalof88casesofelderpatientswithacutecoro—narysyndrome,wererandomlydividedintocontrolgroupandobservationgroup,eachof44patients.Controlgrouppatiewtsweregivenconventionaltherapy.Observationgroupwereaddednadroparincalciuminjectionandnaoxintongca6、psuletreatmentonthebasisofcontrolgroup’sconventionaltherapy.ResIIltsAftertreatment.theimprovementofLVEF,CO,E/Ainobservationgroupwereobviouslybetterthancontrolgroup,thedifferencehadstatisticsignificance(P<0.01).Theattackfrequencyanddurationofanginapectofisinobservationgroupwere(1.9~0.5)time7、severy(1.6±0.4)min,whichwaslowerthan(4.5~1.3)timesevery(4.8~1.2)min,thedifferencehadstatisticsignificance(P<0.01).Totalcholesterol,triglycerideandlowdensitylipoproteincholesterolinobservationgroupwererespectively(5.13~0.53)mmo]fL,(2.34~0.55)mmo1]L,(2.15~0.65)m
3、3~1.1)mg/L,低于对照组的(8.25~2.2)ng/L、(4.2~1.3)mg/L,差异有统计学意义(P<0.01或P<0.05)。结论脑心通胶囊联合低分子肝素钙治疗急性冠脉综合征疗效显著,并能改善患者血清hs—CRP和IL一6及血脂水平。【关键词】脑心通胶囊;低分子肝素钙;急性冠脉综合征;高敏C反应蛋白;白细胞介素6;血脂[中图分类号】R542.2+2【文献标识码】A【文章编号】1673—9701(2014)17—0008—04Naoxintongcapsuleincombinationwithnadroparincalcium’sefectonserumhs—C
4、Rjf'.IL一6andlipidsofpatients、thacutecoronarysyndromeDUXiaomaCAIJiontiSHENXinCardiovascularDepartment,JinhuaCityHospitalofTraditionalChineseMedicineinZhejiangProvince,Jinhua321017,China[Abstract]ObjectiveTostudytheeffectofnaoxintongcapsulecombinationnadroparincalciumonserumhs-CRP,IL-6andlip
5、idsofpatientswithacutecoronarysyndrome.MethodsAtotalof88casesofelderpatientswithacutecoro—narysyndrome,wererandomlydividedintocontrolgroupandobservationgroup,eachof44patients.Controlgrouppatiewtsweregivenconventionaltherapy.Observationgroupwereaddednadroparincalciuminjectionandnaoxintongca
6、psuletreatmentonthebasisofcontrolgroup’sconventionaltherapy.ResIIltsAftertreatment.theimprovementofLVEF,CO,E/Ainobservationgroupwereobviouslybetterthancontrolgroup,thedifferencehadstatisticsignificance(P<0.01).Theattackfrequencyanddurationofanginapectofisinobservationgroupwere(1.9~0.5)time
7、severy(1.6±0.4)min,whichwaslowerthan(4.5~1.3)timesevery(4.8~1.2)min,thedifferencehadstatisticsignificance(P<0.01).Totalcholesterol,triglycerideandlowdensitylipoproteincholesterolinobservationgroupwererespectively(5.13~0.53)mmo]fL,(2.34~0.55)mmo1]L,(2.15~0.65)m
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