国产与进口硝苯地平控释片治疗高血压病比较药学论文开题报告.doc

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1、药学论文•国产与进口硝苯地平控释片治疗高血压病比较作者:朱福，黄波，兰军文，唐志红，蒋庆渊，胡春燕，关雁，丁银林【摘要】目的评价国产硝苯地平控释片治疗高血压病（EH）的临床疗效和不良反应。方法采用随机对照研究高血压病病人120例，60例给予国产硝苯地平控释片（试验组），另外60例服用进口硝苯地平控释片（对照组），均30〜60mg，qdx8周。治疗前后做人工血压测定、24h动态血压测定（ABPM）、血生化检验、血常规、尿常规及心电图。结果国产与进口硝苯地平控释片总有效率分别为95%和97%，显效率为78%和82%，2组比较差

2、异无显著性（P>0・05）；2组服药前、服药后8周的24h、白昼和夜间的平均收缩压、舒张压明显下降，差异有显著性（R0.01），国产与进口硝苯地平控释片服药后8周各时点收缩压和舒张压均较服药前下降，差异有显著性（R0.01）。2组不良反应均轻微。试验组和对照组的不良反应发生率分别为13.3%和11.7%，撤药率分别为1.7%和3.3%（P>0.05），组间比较无统计学差异。结论国产硝苯地平控释片与进口硝苯地平控释片一样治疗高血压病有效、安全，不良反应少，而且有良好的耐受性，是轻、中度高血压满意的降压药物。【关键词】硝苯地平

3、控释片；高血压病；药物评价Domesticvsimportednifedipinecontrolledreleasetabletsintreatmentofessentialhypertention[Abstract]ObjectiveToevaluatetheclinicalefficacyandadversereactionsofdomesticnifedipinecontrolledreleasetabletsinthetreatmentofessentialhyperlent5HZ2MethodsOnehundre

4、dandtwetypatientswithEHwereincluded.Astudyrandomizedwasconducted.Sixtypatientsweretreatedwithdomesticnifedipinecontrolledreleasetablets(Testgroup)，30〜60mg/dandanothersixtypatientsweretreatedwithimportednifedipinecontrolledreleasetablcts(Controlgroup)30〜60mg/dfor8w

5、k.Bloodpressureweretakenbeforeandafterdomesticvsimportednifedipinecontrolledreleasetabletstreatment.24hourambulancebloodpressure»bloodandurineroutine，bloodbiochemics‘ECXjwereexaminedbeforeandaftertreatment.ResultsThetotaleffectiverateofdomesticnifedipinecontrolled

6、releasetabletswas95%remarkableeffectiverateofdomesticnifedipinecontrolledreleasetabletswas78%；whilethoseofimportednifedipinecontrolledrclcssetabletswere97%and82%，therewasnosignificantdifference(P>0.05).Bloodandurineroutine，bloodbiochemicswereunchangedbeforeandafte

7、rtreatment；theadversereactionsweremild.Attheendofthe8thweek，thetwogroupthemeanSBP/DBPof24h，day-timeandnight-timewereobviouslydecreasedandhadsignificantdifferencebeforeandaftertakcn(R0.01).SBPandDBPweredecreasedandhadsignificantdifferenceateverytimepointof24h-ABPMi

8、ntreatment(/^0.01).Theadversereactionratesintestandcontrolgroupswere13.3%and11.7%‘respectively‘andthewithdrawalrateswere1.7%and3.3%，respectively.Nostati