龙胆泻肝汤、消风散、消风散去荆防方对豚鼠急性湿疹疗效比较.pdf

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1、第15卷第12期辽宁中医药大学学报V01．15No．122013年12月JoURNAL0FLIAONINGUNIVERSITY0FTCMDec．．2013龙胆泻肝汤、消风散、消风散去荆防方对豚鼠急性湿疹疗效比较林靓，许日红，滕浦陵(安徽中医药高等专科学校，安徽芜湖241000)摘要：目的：比较龙胆泻肝汤、消风散、消风散去荆防方对豚鼠急性湿疹的疗效。方法：将7％、1％的2，4一二硝基氯苯(DNCB)一丙酮溶液间隔1周，分别涂抹于豚鼠背部去毛皮肤以复制豚鼠急性湿疹模型，口服灌胃给药，并设外用曲咪新乳膏组为药物对照组，据皮损局部的症状评分和组织病理学改变进行疗效评估。结果

2、：龙胆泻肝汤组、消风散去荆防方组的症状评分和组织病理学改变均较模型组有明显改善，龙胆泻肝汤组与外用曲咪新乳膏组无显著差异，消风散去荆防方组优于龙胆泻肝汤组与外用曲咪新乳膏组，消风散组与模型组无显著差异，但消风散组组间差异较大。结论：消风散去荆防方对豚鼠急性湿疹的疗效优于龙胆泻肝汤，龙胆泻肝汤与外用曲咪新乳膏疗效相当，消风散疗效不稳定。关键词：龙胆泻肝汤；消风散；急性湿疹；豚鼠中图分类号：R275．9文献标志码：A文章编号：1673—842X(2013)12—0050—05ComparisononCurativeEffectofLongdanXieganDecocti

3、on，XiaofengPowderandXiaofengPowderwithoutHerbaSchiz0nepetae，RadixSap0shnik0viaeforGuineaPigwithAcuteEczemaLINLiang，XURihong，TENGPuling(AnhuiCollegeofTraditionalChineseMedicine，Wuhu241000，Anhui，China)Abstract：Objective：TheeffectofLongdanXieganDecoction，XiaofengPowderandXiaofengPowderwit

4、houtHerbaSchizonepetae，RadixSaposhnikoviaeforguineapigwithacuteeczemawascompared．Methods：7％and1％of2，4-dinitroehlorohenzene—acetonesolutionswereappliedinthebackofguineapigtoremovehairskineveryotherweektocopyguineapigwithacuteeczemamodelandallthemodelsweregiverndurgwithorallavage．Theguin

5、pigstreatedwithtriamcinoloneacetonideacetateforexternalusewereenrolledindrugcontrolgroupandthecurativeeffectwasevaluatedaccordingtothelocalskinsymptomscoreandhistopath0logicalchange．Resutls：Comparedwithmodelgroup，thesymptomscoreandhist0path0logicalchangeofLongdanXieganDecoctiongroupand

6、XiaofengPowdergroupwereobvioulyimproved；therewasnosignificantdifferencebeweenLongdanXieganDecoctiongroupanddrugcontrolgroup(triamcinoloneacetonideacetateforexternalusegroup)；theeffectofXiao[engPowderwithoutHerbaSchizonepetae，RadixSaposhnik0viaegroupwasbetterthanthatofLongdanXieganDecoc

7、tiongroupanddrugcontrolgroup；theeffectbetweenXiaofengPowderandmodelgroupwasnotsignificant．Conclusions：CurativeefectofXiaofengPowderwithoutHerbaSchiz0nepetae，RadixSap0shnikoviaeforguineapigwithacuteeczemaisbetterthanthatofLongdanXieganDecoction．LongdanXieganDecoctionisparallelswithtri