老年非酒精性脂肪肝与糖代谢异常的相关性分析.pdf

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1、·70·福建医药杂志2014年4月第36卷第2期FujianMedJ，April2014，Vo1．36，No．2·实验诊断与临床·老年非酒精性脂肪肝与糖代谢异常的相关性分析福建医科大学省立临床医学院福建省立医院干部特诊一科(福州350001)李小明【摘要】目的分析中老年人群非酒精性脂肪肝(NAFLD)与糖代谢异常的相关性及发生糖代谢异常的相关危险因素。方法体检中心423例既往无糖尿病病史的中老年人群(>5O岁)，通过B超筛查分为非酒精性脂肪肝组(NAFLD)和对照组。两组人群均记录相关病史，测量身高、体质量、腰围、臀围、血压，采血检测空腹血糖、血脂等生

2、化指标，并检测75g葡萄糖负荷后2h血糖，计算体质量指数(BMI)、腰臀比(WHR)；采用Logistic回归分析NAFLD与糖代谢异常的相关性结果NAFLD组的BMI、WHR、收缩压(SBP)、舒张压(DBP)、ALT、AST、UA、FBG、P2hBG、TG、TC水平明显高于非NAFLD组(P

3、．001)，TG、ALT、WHR也与糖代谢异常独立相关。结论中老年人群NAFID与糖代谢异常表现独立正相关；而TG、WHR与糖代谢异常发生密切相关。【关键词】非酒精性脂肪肝；糖代谢异常；糖尿病【中圈分类号】R575．5；R589．1【文献标识码】A【文章编号】1002-2600(2014)02-0070-03Researchontherelationshipbetweennonalcoholicfattyliverdiseaseandvariousglucoseprofilesinelderlypop—ulationLIXiaoming．Departm

4、entoftheFirstSpecialCadreTreatment，FujianProvincialHospital，ProvincialClinicalMedicalCollegeofFujianMedicalUniversity，Fuzhou，Fujian350001，China[Abstract]0bjectiveToexploretherelationshipbetweennonalcoh'olicfattyliverdisease(NAFLD)andvariousglucoseprofiles，andtheriskfactorsofimpa

5、iredglucosemetabolisminelderlypopulation．MethodsAtotalof423populationwithoutpriorknowndiabetesmellitusweredividedintotwogroups：NAFLDgroupandwithoutNAFLDgroup，matchedforsexandage．ResultsThepeoplewithNAFLDhadhigherbodymassindex，waist—to—hipratio(WHR)，systolicbloodpressure，dias—tol

6、icbloodpressure，ALT，AST，UA，FBG，P2hBG，TGandTCthanthepeoplewithoutNAFLD(P<0．05)．However，thepeoplewithNAFLDhadlowerHDL—C(P

7、ypredictedim—pairedglucosemetabolism(OR一1．86，1．51～2．28，P<0．001)afteradjustmentforallpotentialconfounders．Moreover，tri—glyceride，ALTandWHRwerealsoassociatedwithimpairedglucoseprofiles．ConclusionsTheseresultssuggestthatNAFLDisassociatedwithimpairedglucoseprofilesindependenofmultip

8、lemetabolicabnormalitiesinelderlypopulation．Tri