血浆PTX3检测在预测急腹症并发全身炎症反应综合征患者预后中的临床意义-论文.pdf

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1、临床研究Linchuangyanjiu《中国医学创新》第11卷第18期(总第30o期)2014年6月血浆PTX3检测在预测急腹症并发全身炎症反应综合征患者预后中的临床意义术朱世纯①4~4t~张文丽②蒙国光①李广洲①【摘要l目的：观察急腹症并发全身炎症反应综合征(systemicinflammatoryresponsesyndrome，SIRS)患者血浆正五聚素(pentraxin3，PTX3)水平的动态变化，探讨PTX3在预测急腹症并发全身炎症反应综合征患者预后中的临床意义。方法：选取107例符合SIRS诊断的急腹症患者，分别于

2、入院当日(0d)及入院后1、5d清晨采集空腹外周静脉血，用酶联免疫吸附法(ELISA)检测PTX3的血浆浓度，并设60例健康体检者为对照组予以比较。结果：107例急腹症并发全身炎症反应综合征患者的各监测点的PTX3水平均明显高于对照组，且并发症组患者血浆各监测点的PTX3水平均明显高于无并发症组，差异均有统计学意义(P<0．05o结论：急腹症并发sIRs时，PTX3表达增多，其升高程度与全身炎症反应综合征的严重程度及术后并发症发生密切相关。【关键词】急腹症；全身炎症反应综合征；正五聚素ClinicalSignificanceof

3、PlasmaPTX3DetectioninPredictingthePrognosisofPatientswithAcuteAbdomenComplicatedwithSystemicInflammatoryResponseSyndrome／ZHUShi-chun。LIQian，ZHANGWen—li。etalJ／MedicalInnovationofChina。20l4。11(18)：052-054【Abstract】Objective：Toobservethedynamicchangesinserumcytokineslev

4、elsofPTX3andinvestigatetheclinicalsignificanceofplasmaPTX3detectioninpredictingtheprognosisofpatientswi出acuteabdomencomplicatedwithsystemicinflammatoryresponsesyndrome(SIRS)．Method：107patientswithacuteabdomencomplicatedwithsystemicinflammatoryresponsesyndromeweresele

5、cted，theperipheralvenousbloodwerecollectedOnthedayofadmission，and1，5daysafteradmissionrespectively．Thelevelsofpentraxin3(PTX3)weredetectedbyenzyme-linkedimmunosorbentassay，selected6Ohealthypersonsascontrolgroup。andcomparedwiththeirresults．Result：ThelevelsofPTX3in107p

6、atientswithacuteabdomencomplicatedwithsystemicinflammatoryresponsesyndromeateachmonitoringpointweresignificantlyhigherthanthoseinthecontrolgroup，andthelevelsofPTX3inthecomplicationgroupateachmonitoringpointweresignificantlyhigherthanthoseinthenocomplicationgroup．tlle

7、diferenceswerestatisticallysignificant(P<0．05lConclusion：InacuteabdomenpatientscombinedwithSIRS，thelevelsofPTX3aleincreased．PTX3elevatedlevelsandsystemicinflammatoryresponsesyndromeiscloselyrelatedtotheseverityandpostoperativecomplications．【KeywordslAcuteabdomen；Syst

8、emicinflammatoryresponsesyndrome；Pentraxin3First-author’Saddress：ThePeople’SHospitalofFengrunDistrictinTangshanCity。Tangshan064000，