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《限制型心肌病患者心内膜心肌活检的组织学病理特点及心功能变化.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、海南医学2014年10月第25卷第19期HainanMedJ,Oct.2014,V01.25,No.19doi:10.3969/j.issn.1003—6350.2014.19.1151·临床病理·限制型心肌病患者心内膜心肌活检的组织学病理特点及心功能变化洪舟,潘龙飞,杜英俊(1.西安市第五医院急诊科,陕西西安710082;2.西安交通大学第二附属医院急诊科,陕西西安710004;3.西安市第五医院病理科,陕西西安710082)【摘要】目的探讨限制型心肌病患者心内膜心肌活检的组织学病理特点以及相共功能变化。方法对我院急诊科2010年1月至2013年10月
2、收治的40例限制型心肌病患者(心肌病组)进行心内膜心肌活检,并做实验室检查、右心导管以及心肌病理检查,对其结果进行分析,并与40例正常对照组比较。结果心肌病组的B型利钠肽(BNP)、肌酸激酶同工酶(CK-MB)和肌钙蛋白I(Tn1)明显高于对照组(P均<0.05);心肌病组的右心房压、右心室收缩压、右心室舒张末压和肺动脉楔压明显高于对照组[右心房压:(18.74-4.5)mmHgVS00.24-1.4)mmHg;右心室收缩压:(46.54-5.6)mmHgVS(34.74-3.7)mmHg;右心室舒张末压:(16.34-4.6)mmHgvs(8.64-2
3、.6)mmHg;肺动脉楔压:(28.64-5.3)mmHgVS(14.24-3.8)mmHg,P均4、hologicalfeatures,cardiacfunctionofrestrictivecardiomyopathybyendomyocardialbiopsy.HONGZhou5、PANh,ng-fei2DUYing-jun3.1。EmergencyDepartment,theFifthHospitalofXi"an,Xi"an710082,Shaanx~CHINA;2.Emergency~partment,theSecondAfiliatedHospitalofXi"anJiaoTongUniversity,Xi"an710004,Shaanxi,6、CHINA;3.DepartmentofPathology,theFifthHo~imlofXi"an,Xi"an710082,Shaanxi,CHINA【Abstract】ObjectiveToexplorethehistologicalandpathologicalfeaturesofrestrictivecardiomyopathybyendomyocardialbiopsy,aswellascardiacfunctionchanges.MethodsFromJanuary2010toOctober2013,40pa-tientsofrestric7、tivecardiomyopathyfromtheEmergencyDepartment(cardiomyopathygroup)weretreatedbyendo-myocardialbiopsy,laboratorytests.rightheartcatheterizationandcardiacpathology.Theresultswereanalyzedandcomparedwiththatof40healthyindividuals(thecontrolgroup).ResultsThelevelsofB-typenatriureticpep8、tide(BNP),CK-MBandTnIofcardiomyopathygroupweresignificantlyhigherthanthoseofthecontrolgroup(P<0.05);Therightatrialpressure,rightventricularsystolicpressure,rightventricularend·diastolicpressureandpulmonaryar-terywedgepressureofcardiomyopathygroupweresignificantlyhigherthanthecont9、rolgroup:rightatrialpressure:(18.74-4.5)
4、hologicalfeatures,cardiacfunctionofrestrictivecardiomyopathybyendomyocardialbiopsy.HONGZhou
5、PANh,ng-fei2DUYing-jun3.1。EmergencyDepartment,theFifthHospitalofXi"an,Xi"an710082,Shaanx~CHINA;2.Emergency~partment,theSecondAfiliatedHospitalofXi"anJiaoTongUniversity,Xi"an710004,Shaanxi,
6、CHINA;3.DepartmentofPathology,theFifthHo~imlofXi"an,Xi"an710082,Shaanxi,CHINA【Abstract】ObjectiveToexplorethehistologicalandpathologicalfeaturesofrestrictivecardiomyopathybyendomyocardialbiopsy,aswellascardiacfunctionchanges.MethodsFromJanuary2010toOctober2013,40pa-tientsofrestric
7、tivecardiomyopathyfromtheEmergencyDepartment(cardiomyopathygroup)weretreatedbyendo-myocardialbiopsy,laboratorytests.rightheartcatheterizationandcardiacpathology.Theresultswereanalyzedandcomparedwiththatof40healthyindividuals(thecontrolgroup).ResultsThelevelsofB-typenatriureticpep
8、tide(BNP),CK-MBandTnIofcardiomyopathygroupweresignificantlyhigherthanthoseofthecontrolgroup(P<0.05);Therightatrialpressure,rightventricularsystolicpressure,rightventricularend·diastolicpressureandpulmonaryar-terywedgepressureofcardiomyopathygroupweresignificantlyhigherthanthecont
9、rolgroup:rightatrialpressure:(18.74-4.5)
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