外用青黛治疗桥本甲状腺炎疗效及其对甲状腺自身免疫性抗体的影响.pdf

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1、·24·ChineseJournaloflnformationonTCMNov．2014VoI．21No．11外用青黛治疗桥本甲状腺炎疗效及其对甲状腺自身免疫性抗体的影响张毅，张敏，黄宁静上海市中医医院内分泌科，上海200071摘要：目的观察外用青黛对桥本甲状腺炎(HT)血清中甲状腺球蛋白抗体(TGAb)、甲状腺过氧化物酶抗体(TP0Ab)的影响。方法将65例HT患者随机分为治疗组33例和对照组32例。2组甲状腺功能亢进、甲状腺功能减退者分别予甲巯咪唑片10mg／d、左旋甲状腺素片25~50g／d控制甲状腺功能，稳定2周后，治疗组在此基础上于颈前甲状腺投射区域局部外敷青黛治疗，疗程6个月

2、。结果中医临床证候2组均有改善，组间比较差异有统计学意义(P<0．05，P

3、中医药疗法D0I：10．3969／3．issn．1005—5304．2014．11．008中图分类号：R259．814文献标识码：A文章编号：1005—5304(2014)1l一0024—04EficacyofIndigoNaturalisTopicalTreatmentofHashimoto’SThyroiditisandItsEfectsonSerumTGAbandTPOAbZHANGYi，ZHANGMin，HUANGNing~ing(EndocrinologyDepartment,ShanghaiTraditionalChineseMedicineHospital,Shanghai

4、200071，China)Abstract：ObjectiveToobservetheeficacyoftopicalindigonaturalisontheserumthyroglobulinantibody(TGAb)andthyroidperoxidaseantibody(TPOAb)inHashimoto’Sthyroiditis(HT】．MethodsSixty—fivecasesofHTwererandomlydividedintothetreatmentgroup(33cases)andthecontrolgroup(32cases)．Hyperthyroidismpati

5、entsandhypothyroidismpatientsinthetwogroupsweretreatedwithmethimazole10mg／dandlevothyrocine25—50Ug／dtocontroltheirthyroidfunction．Basedonthebasictreatment，patientsinthetreatmentgroupweretreatedwithtopicalindigonaturalislocalexternalapplication，whichlastedfor6months．ResultsTCMclinicalsymptomswerei

6、mprovedinbothtwogroups，withstatisticalsignificancebetweenthetwogroups(P

7、71．88％(23／32)，withstatisticalsignificancebetweenthetwogroups(P