透明质酸对膝骨关节炎患者关节液中脂联素和瘦素水平的影响.pdf

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1、中华关节外科杂志(电子版)2015年2月第9卷第1期ChinJJointSurg(ElectronicEdition)，February2015，Vo1．9，No．1·41·临床论著·透明质酸对膝骨关节炎患者关节液中脂联素和瘦素水平的影响骆家伟方斌【摘要】目的观察透明质酸的对膝骨关节炎患者关节液中脂联素和瘦素水平的影响。方法选择2012年10月至2013年1O月期间到本组就诊的单侧膝骨关节炎35例，所有患者均采用关节内注射透明质酸的治疗。采用患侧膝关节Kellgren—Lawrence分级评价膝骨关

2、节炎严重程度，其中2级12例、3级12例、4级11例。参照SF-36量表评估患者的生存质量，酶联免疫吸附法(ELISA)检测治疗前后关节液中脂联素和瘦素浓度的变化。结果与治疗前相比，治疗后KL一2级患者改良sF．36量表中疼痛因素、功能因素和心理因素评分改善(P均大于0．05)；KL一3级和KL-4级患者疼痛因素、功能因素和心理因素评分均无明显改变(P均大于0．05)；与治疗前相比，治疗后KL-2级患者关节液中脂联素和瘦素水平分别下降了57．8％(P<0．01)和29．6％(P<0．05)；KL-4

3、级患者关节液中脂联素和瘦素水平分别升高了62．9％(P<0．O1)和139．7％(P<0．05)；KL．3级患者关节液中脂联素和瘦素无明显改变(P均大于0．05)。结论关节腔内注射透明质酸钠治疗KL-2级伴有疼痛的膝骨关节炎患者疗效确切，作用效果可能与关节液中脂联素和瘦素水平降低有关。【关键词】骨关节炎，膝；透明质酸；脂联素；瘦素EfectsofhyaluronicacidonadiponectinandleptininsynovialfluidofpatientsHthkneeosteoarthr

4、itisLuoJiawei，FangBin．DepartmentofOrthopaedics，XiegangHospitalofDongguanCity，Dongguan523590，China；DepartmentofOrthopaedics，DepartmentofOrthopaedics，TheFirstAfiliatedHospitalofGuangzhouUniversityofhineseMedicine，Guangzhou510407，ChinaCorrespondingauthor：

5、Bin，Email：kzxfang@yahoo．corn．cn【Abstract】0bjectiveToobservetheeffectsofsodiumhyaluronate(SH)onadiponectinandleptininthesynovialfluidinthepatientswithkneeosteoarthritis(KOA)．MethodsAtotalof35patientswithosteoarthritisoftheunilateralkneewhoparticipatedin

6、thisstudywereevaluatedfromOctober2012toOctober2013．Allthepatientsweregivenintra—articularinjectionofSHasatreatmentmedication．Toevaluatetheseverityofthekneeosteoarthritis，theKellgren—LawrenceGradewasperformed，accordingtowhich，therewere12easesofgrade2、12

7、casesofgrade3and11casesofgrade4．TheimpovedSF一36scalewasusedtoassessthequalityoflife；theadiponectinandleptinlevelsinthesynovialfluidweredeterminedbyenzyme—linkedimmunosorbentassay(ELISA)．ResultsComparedtothepre—treatmentdata，thepainscale，functionscalean

8、dpsychologyscaleinthepatientsofKLgrade2wereimprovedafterthetreatment(P<0．05)；nosignificantdiferencewasfoundinthepatientsofKLgrade2andgrade3betweenthepre—treatmentdataandthepost—treatmentdata(P>0．05)．Comparedtothepre—treatmentdata，theadi