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时间:2020-05-19
《泮托拉唑对肝癌细胞SMCC-7721迁移、侵袭及凋亡的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中国医药导报2015年5月第12卷第13期论著·泮托拉唑对肝癌细胞SMCC-7721迁移、侵袭及凋亡的影响蔡孝莉冉丽丹文国容金海庹必光遵义医学院附属医院消化内科,贵州遵义563000【摘要】目的观察泮托拉唑对人肝癌细胞SMMC一7721迁移、侵袭及凋亡的影响,预测其对人肝癌的抗癌作用。方法体外培养人肝癌细胞SMMC一7721细胞,细胞迁移和侵袭实验分为对照组和泮托拉唑不同浓度组(20、40、80、120、160I~mol/L),对其进行干预,用细胞小室(Transwel1)观察其对肝癌细胞迁移能力的影响;用
2、Transwell小室上铺设基质胶观察泮托拉唑对细胞侵袭的影响;细胞凋亡实验分为对照组和泮托拉唑不同浓度组(40、80、160、320、640Ixmol/L),用流式细胞仪检测其对细胞凋亡的影响。结果泮托拉唑20I~mol/L组对人肝癌细胞SMMC一7721的迁移和侵袭与对照组比较差异无统计学意义(P>0.05),而泮托拉唑40、80~moFL组与对照组比较差异有统计学意义(P<0.05),并且泮托拉唑120、160Ixmol/L组与对照组比较差异均有高度统计学意义(P<0.01):另外,泮托拉唑40Ixm
3、ol/L组对人肝癌细胞SMMC一7721的凋亡与对照组比较差异无统计学意义(P>0.05),而泮托拉唑80、160、320、640Ixmol/L组与对照组比较差异有统计学意义(P<0.05或P4、ion,invasionandapoptosisofhumanlivercarcinomaSMCC-7721cellsCAIXiaoliRANLidanWENGuorongJINHalTUOBiguangDepartmentofGastroenterology,AffiliatedHospitalofZunyiMedicalUniversity,GuizhouProvince,Zunyi563000,China【Abstract]ObjectiveToinvestigatetheeffectsofPanto5、prazoleonthemigration,invasionandapoptosisofhumanlivercarcinomaSMMC-7721cell,andtopredictitsanti—cancereffectonlivercancer.Methods/nvitrocultivationofhu—manlivercarcinomaSMMC一7721cells.cellmigrationandinvasionexperimentsweredividedintocontrolgroupanddiffer6、entconcentrationsofPantoprazolegroups(20,40,80,120,160~mol/L),TranswellchamberassaywasusedtodetectthemigrationofSMMC-7721cells.TranswellchamberassaywasusedtodetecttheinvasionofSMMC—-7721cells.Cellapoptosisexperimentwasdividedintocontrolgroupanddifferentcon7、centrationsofPantoprazolegroups(40,80,160,320,640Ixmol/L),FCMtestwasusedtodetecttheapoptosisofSMMC-7721cells.ResultsThemigrationandinvasionofPantoprazole20Ixmol/LgrouphadnostatisticallysignificantdifferencesinSMMC—-7721cellscom.paredwithcontrolgroup(P>0.058、),whilePantoprazole40,80I~mol/Lgrouphadastatisticallysignificantdifferencecomparedwithcontrolgroup(尸<0.05),andPantoprazole120,160{xmol/Lgroupwerehighlystatisticallysignificantdifferentcomparedwithcontrolgroup
4、ion,invasionandapoptosisofhumanlivercarcinomaSMCC-7721cellsCAIXiaoliRANLidanWENGuorongJINHalTUOBiguangDepartmentofGastroenterology,AffiliatedHospitalofZunyiMedicalUniversity,GuizhouProvince,Zunyi563000,China【Abstract]ObjectiveToinvestigatetheeffectsofPanto
5、prazoleonthemigration,invasionandapoptosisofhumanlivercarcinomaSMMC-7721cell,andtopredictitsanti—cancereffectonlivercancer.Methods/nvitrocultivationofhu—manlivercarcinomaSMMC一7721cells.cellmigrationandinvasionexperimentsweredividedintocontrolgroupanddiffer
6、entconcentrationsofPantoprazolegroups(20,40,80,120,160~mol/L),TranswellchamberassaywasusedtodetectthemigrationofSMMC-7721cells.TranswellchamberassaywasusedtodetecttheinvasionofSMMC—-7721cells.Cellapoptosisexperimentwasdividedintocontrolgroupanddifferentcon
7、centrationsofPantoprazolegroups(40,80,160,320,640Ixmol/L),FCMtestwasusedtodetecttheapoptosisofSMMC-7721cells.ResultsThemigrationandinvasionofPantoprazole20Ixmol/LgrouphadnostatisticallysignificantdifferencesinSMMC—-7721cellscom.paredwithcontrolgroup(P>0.05
8、),whilePantoprazole40,80I~mol/Lgrouphadastatisticallysignificantdifferencecomparedwithcontrolgroup(尸<0.05),andPantoprazole120,160{xmol/Lgroupwerehighlystatisticallysignificantdifferentcomparedwithcontrolgroup
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