透明质酸制备工艺进展(1)(2) (1)

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1、滨州学院毕业生论文透明质酸制备工艺进展摘要透明质酸，又名玻璃酸，是一种独特的。它是由线性大分子酸性粘多糖葡萄糖醛酸和N—乙酞氨基葡萄糖的双糖单位重复连接形成的。透明质酸广泛分布于高等动物的细胞外基质、结缔组织和器官中。透明质酸以其独特的分子结构和理化性质在机体内显示多重要的生理功能，如润滑关节，促进创伤愈合等，在临床上得到广泛的应用。HA及其衍生物具有优良的生物相容性和可降解性，能作为药物载体和组织工程材料，因而广泛应用于生物医药学领域。透明质酸还具有特殊的保水作用，是目前发现的自然界中保湿性最好的物质，被誉

2、为最为理想的天然保湿因子，已作为化妆品及使用保健品中的保湿添加剂使用。文章讨论了透明质酸的制备方法，并对其在医药、化妆品、保健食品等领域中的应用进行综述。关键词：线性大分子酸性多糖;天然保湿因子;保湿添加剂;相溶性;可降解性滨州学院毕业生论文HyaluronicacidpreparationprocessAbstractHyaluronicacid,alsoknownashyaluronicacid,isaunique.Itiscomposedoflinearmacromolecularacidmucopol

3、ysaccharideglucuronicacidandN-acetylglucosaminedisacchariderepeatingunitsareconnectedtoforma.Hyaluronicacidiswidelydistributedinhigheranimalcells,extracellularmatrixofconnectivetissuesandorgans.Hyaluronicacidwithitsuniquemolecularstructureandphysicochemical

4、propertiesinvivoshowsmanyimportantphysiologicalfunctions,suchaslubricationofjoints,promotewoundhealing,hasbeenwidelyappliedinclinicalmedicine.HAanditsderivativeshavebiocompatibilityandbiodegradabilityhasexcellentbiocompatibility,canbeusedasdrugdeliveryandti

5、ssueengineeringmaterial,whichiswidelyusedinbiomedicalfield.Hyaluronicacidalsohasaspecialroleinwaterretention,isthemoistureofnaturefoundinthebestmaterial,knownasthemostnaturalmoisturizingfactorideal,ascosmeticsandhealthcareproductsintheuseofmoisturizingaddit

6、ives.Thispaperdiscussesthemethodofthepreparationofhyaluronicacid,andreviewsitsapplicationinmedicine,cosmetics,healthfoodandotherfields.Keywords:Linearmacromoleculesofacidicpolysaccharides;naturalmoisturizingfactor;hydratingadditives;miscibility;biodegradabi

7、lity滨州学院毕业生论文目录引言·······························································1第一章透明质酸的简介··············································1第二章透明质酸的制备及原理········································22.1组织提取法······················································22.

8、2微生物发酵法···················································22.3人工合成法·····················································2第三章透明质酸在实际中的应用·······································33.1药物缓释体系中及临床医学中的应用·······