抗ICOS免疫疗法抑制鼠心脏移植的加速性和慢性排斥反应.pdf

《抗ICOS免疫疗法抑制鼠心脏移植的加速性和慢性排斥反应.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、中织]氍究与临眯羽’7444叨2010—10—29版JournalofClinicalRehabilitativeTissueEngineeringResearchOctober29,2010VoL14，No．44死Anti--induciblecostimulatorimmunotherapyinhibitsacceleratedandchroniccardiacallograftrejectionsrats；I-'~rSunZhi—peng，Aminbuhe，ZhuBin，GongKe，ZhangNeng—weAbstractDeDartmentofGeneralSurgeryBACKGR

2、0UND：lnaDA(RT1)loLEW(RT1’)ratmodel，jnhibitionofB7-CD28co—stimulatorysignalblockadebyBeijingSijitanadenovirus-mediatedcytotoxicT—lymphocyte-associatedantigen4immunoglobulin(AdCTLA-41g)induceslong—ter丌1Hospital，Beijingacceptanceofcardiacallografts．However．alografttolerancejsincompleteandrejectionevent

3、ualyoccurs．1nparticular，100038．Chinadonor-typeskingraftingtorecipientswithfunctionaIcardiacallograftscausesacceleratedheartrejection．OBJECTIVE：Toevaluatethecombinedefectsofinducibleco-stimulator(ICOS)therapyandAdCTLA-41gtreatmentonSunZhi—peng*，Master,Physician．preventingacceleratedcardiacrejectionca

4、usedbydonor—strainskingraftingandvalidatethatICOStherapycanblockDepartmentofacceleratedcardiacrejection．nomatterwithorwithoutAdCTLA·41gtreatment．GeneralSurgery，METHODS：DAheartsweretransplantedintotheabdominaIcavityofLEvvrecipients．TherecipientsintravenouslyreceivedaBeijingSijitansingledoseof10plaque

5、—formingunitsofAdCTLA一41gimmediatelyaftertransplantation．Recipientswithgraftssurviving>50Hospital，Beijingdaysweregivenafull—thicknessdonor·typeskingrafttotheIateraIthoracicwal1．Theserecipientsreceivedintravenous100038．Chinasunzhipeng56084@injectionofanti·ICOSantibody(1mg，kg)orcontrolIgGfromthe50day，

6、onceeveryotherday，for2weeks．Completegraft163．corntel’ectionwasdefinedascessationofbeatingandwashistologicalyconfirmedbymononuctearcellinfiltrationandcardiacmyocytenecrosisusinghematoxylinandeosinstainingofgraftsections．Correspondenceto：RESULTSANDCONCLUSl0N：CardiacsectionsofAdCTLJ·41g—treatedrecipien

7、tssurviving>100daysshowedtypicalZhangNeng-weiICOS-positivemononuclearcelIInfiltrationandvasculopathy．AdCTLA一41gtreatmeritcombinedwithanti—ICOStherapyDoctor,Chiefinducedstabletolerancetochronicrejectio