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时间:2020-05-12
《放化疗联合胸腔镜手术治疗ⅢA N2期非小细胞肺癌的临床效果.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、实用医学杂志2014年第3O卷第19期3099InfarctionPeptide(LAMP)study[J].Circulation,2007,115[11]RayP,CharpentierS,C,eta1.Combined(16):2103-2110.copeptinandtroponintoruleoutmyocardialinfarctionin[10]CharpentierS,Maupas—SchwalmF,CournotM,eta1.Combinationpatientswithchestpainandahistoryofc
2、oronaryarterydiseaseofcopeptinandtroponinassaystorapidlyruleoutnon—ST[J].AmJEmergMed,2012,30(3):44O一448.elevationmyocardialinfarctionintheemergencydepartment[J].(收稿:2013—09—29编辑:张倩)AcadEmergMed,2012,19(5):517-524.放化疗联合胸腔镜手术治疗ⅢAN2期非小细胞肺癌的临床效果翟小明顾科俞家华王建平张军宁摘要目的:观察放化疗联合胸腔镜
3、手术治疗ⅢAN2期非小细胞肺癌(NSCLC)患者的临床效果。方法:ⅢA期N2NSCLC患者8O例.40例行胸腔镜手术为研究组。40例行传统开胸手术为对照组。术后均予诺维本联合顺铂化疗4个周期,每3周为1个周期。化疗后7~14d给予6MV—X线适形放疗50Gy/25次/35d。比较2组的1、2年生存率、完成总疗程时间及毒副反应。结果:研究组患者总疗程时间明显缩短(x=9.45,P=0.002),术后化疗开始时间明显缩短(x=41.32,P=0.00),治疗后KPS评分明显升高(x=15.12.P=0.002)。2组患者的骨髓抑制、消化道
4、反应及1、2年生存率无明显差异。结论:ⅢA期N2NSCLC患者胸腔镜术后化放疗可以达到较好疗效,且手术创伤小,住院时间短,术后恢复快,可以缩短术后辅助化疗开始的时间及总的疗程时间,值得进一步研究及推广。关键词癌,非小细胞肺;胸腔镜;化疗;放疗ClinicaleficacyofthoracoscopicsurgerycombinedwithchemoradiotherapyinpatientswithN2stagemAnon-smallcelllungcancerZHA1Xiao-ming,GUKe,YU五0一hua,WANGJian-
5、ping,ZHANGJun—ning.DepartmentofRadiationOncology,FirstAffiliatedHospital,SuzhouUniversity,Suzhou215006,ChinaCorrespondingauthor:GUKeE—mail:dr.guke@hotmail.con【Abstract】ObjectiveToevaluatetheclinicaleficacyofthoracoscopicsurgerycombinedwithchemorad—iotherapyinpatientswit
6、hN2stageIIIAnon-smallcelllungcancer(NSCLC).Methods40patients(studygroup)receivedthoracoscopicsurgeryandanother40patients(controlgroup)receivedtraditionalthoracotomy.Combinationtherapywithnavelbineandcisplatinwerepostoperativelyadministeredforfourcyclesandonecyclelastedf
7、or3weeks.7to14daysafterchemotherapy,sequentialconformalradiotherapyweredelivered.Theone—yearsurvivalandtwo—yearsurvivalrates,durationoftataltreatment,andadversereactionswerecomparedbetweenthetwogroups.ResultsInthestudygroup,durationoftotaltreatmenttimeandtimetopostopera
8、tivechemotherapyweresignificantlyshorter(x=9.45,P=0.002andx=41.324,P=0.000),andtheKPSscorewassignificantlyhigh
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